Function and modulation of ionotropic glutamate receptors.
Ionotropic glutamate receptors are ligand-gated ion channels responsible for excitatory synaptic transmission in the central nervous system. My laboratory is interested in studying the function and modulation of ionotropic glutamate receptors. Some of the subunits of NMDA receptor have not received as much attention as others and their physiological importance remains unclear. We are interested in the basic physiology of these receptors and their modulation by potential drugs for neurodegenerative diseases and mental disorders. Another area of interest is in studying the modulation of synaptic transmission by G-protein coupled receptors. We have found that activation of certain G-protein coupled receptors modulate synaptic transmission and are currently involved in investigating the mechanisms involved in this phenomenon. We utilize a range of electrophysiological, calcium imaging and molecular biology techniques including single channel and whole cell recording to investigate these aims.
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