Kenneth S. Thomson, Ph.D.
Appointment(s) and Titles:
Professor, Medical Microbiology and Immunology, Creighton University
Director, Center for Research in Anti-Infectives and Biotechnology, Creighton University
Education:
Ph.D., University of Tasmania, 1988
Research Interests:
Antibiotics.
Selected Publications:
Thomson, K.S., Weber, D.A., Sanders, C.C. and Sanders, W.E. Jr. 1990. b-lactamase production in Enterobacteriaceae and resistance to b-lactam/enzyme inhibitor combinations. Antimicrob. Agents Chemother. 34:622-627.
Thomson, K.S. and Sanders, C.C. 1992. Detection of extended-spectrum b-lactamases in Enterobacteriaceae: comparison of the double disk and 3-dimensional tests. Antimicrob. Agents Chemother. 36:1877-1882.
Thomson, K.S. and Sanders, C.C. 1997. A simple and reliable method to screen isolates of Escherichia coli and Klebsiella pneumoniae for the production of TEM- and SHV-derived extended-spectrum b-lactamases. Clin. Microbiol. Infect. 3:549-554.
Thomson, K.S., Sanders, C.C. and Smith Moland, E. Use of Microdilution Panels with and without b-lactamase Inhibitors as a Phenotypic Test for b-lactamase Production among Escherichia coli, Klebsiella spp., Enterobacter spp., Citrobacter freundii, and Serratia marcescens. Antimicrob. Agents Chemother. 43:1393-1400.
Thomson, K.S. Extended Spectrum and AmpC Beta-Lactamases: Controversies. Emerging Infectious Diseases, 2001, 7:333-336.
Moland, E.S., Black, J.A. Ourada, J., Reisbig, M.D., Hanson, N.D. and Thomson, K.S. Occurrence of Newer β-lactamases in Klebsiella pneumoniae Isolates from 24 United States Hospitals. Antimicrob. Agents Chemother. 2002 46 3837-3842.
Moland, E.S., Hanson, N.D., Herrera, V.L., Black, J.A., Lockhart, T.J., Hossain, A, Johnson, J.A., Goering, R.V., and Thomson, K.S. Plasmid-mediated, carbapenem-hydrolyzing β-lactamase, KPC-2, in Klebsiella pneumoniae isolates J. Antimicrob. Chemother. 2003 51 711-714.
Moland, E.S., Black, J.A., Hossain, A., Hanson, N.D., Thomson, K.S. and Pottumarthy, S. Discovery of CTX-M-like extended-spectrum beta-lactamases in Escherichia coli isolates from five US States. Antimicrob. Agents Chemother. 2003 47:2382-2383.
Thomson, K.S. and Lister, P.D. Other ß‑lactam antibiotics. In: "Infectious Diseases", Third Edition, Eds. Gorbach, S.L., Bartlett, J.G., and Blacklow, N.R., W. B. Lippincott Williams & Wilkins, 2004, 204-208.
Thomson, K.S. and Moland E.S. CS-023 (R-115685), novel carbapenem with enhanced in vitro activity against oxacillin-resistant staphylococci and Pseudomonas aeruginosa. J. Antimicrob. Chemother. 2004 54: 557-562.
Hossain, A., Ferraro, M.J., Pino, R.M., Dew, R.B., 3rd, Moland, E.S., Lockhart, T.J., Thomson, K.S., Goering, R.V., Hanson, N.D. Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp. Antimicrob Agents Chemother 2004 48: 4438-4440.
Song, W., Moland, E. S., Hanson, N. D., Lewis, J. S., Jorgensen, J. H., and Thomson, K. S. Failure of Cefepime Therapy in Treatment of Klebsiella pneumoniae Bacteremia. J Clin Microbiol 2005 43:4891-4894.
Black, J. A., E. S. Moland, and K. S. Thomson.. AmpC disk test for detection of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking chromosomal AmpC β-lactamases. J Clin Microbiol 2005 43:3110-3113.
Wickman, P.A., E. S. Moland, J. A. Black, and K. S. Thomson 2006. In vitro activity of DX-619, a novel des-fluoro(6) quinolone, against a panel of Streptococcus pneumoniae mutants with characterized resistance mechanisms Antimicrob. Agents Chemother. 50:796-798.
Wickman, P. A., J. A. Black, E. S. Moland, and K. S. Thomson. 2006. In vitro activities of DX-619 and comparison quinolones against gram-positive cocci. Antimicrob Agents Chemother 50:2255-2257.
Hanson, N. D., A. Hossain, L. Buck, E. S. Moland, and K. S. Thomson. 2006. First occurrence of a Pseudomonas aeruginosa isolate in the United States producing an IMP metallo-beta-lactamase, IMP-18. Antimicrob Agents Chemother 50:2272-2273.
Moland, E. S., N. D. Hanson, J. A. Black, A. Hossain, W. Song, and K. S. Thomson. 2006. Prevalence of Newer β-lactamases in Gram-Negative Clinical Isolates Collected in the United States from 2001 to 2002. J Clin Microbiol 44:3318-3324.
Wickman, P. A., J. A. Black, E. Smith Moland, K. S. Thomson, and N. D. Hanson. 2006. In vitro development of resistance to DX-619 and other quinolones in enterococci. J. Antimicrob. Chemother. 58:1268-1273.
Moland, E. S., S. G. Hong, K. S. Thomson, D. H. Larone, and N. D. Hanson. 2007. Klebsiella pneumoniae isolate producing at least eight different beta-lactamases, including AmpC and KPC beta-lactamases. Antimicrob Agents Chemother 51:800-1.
Thomson, K. S., N. E. Cornish, S. G. Hong, K. Hemrick, C. Herdt, and E. S. Moland. 2007. Comparison of Phoenix and VITEK 2 extended-spectrum-beta-lactamase detection tests for analysis of Escherichia coli and Klebsiella isolates with well-characterized beta-lactamases. J Clin Microbiol 45:2380-4.
Kim, S. Y., S. G. Hong, E. S. Moland, and K. S. Thomson. 2007. Convenient Test Using a Combination of Chelating Agents for Detection of Metallo-{beta}-Lactamases in the Clinical Laboratory. J Clin Microbiol 45:2798-801
Moland, E. S., D. W. Craft, S. G. Hong, S. Y. Kim, L. Hachmeister, S. D. Sayed, and K. S. Thomson. 2008. In Vitro Activity of Tigecycline against Multidrug-Resistant Acinetobacter baumannii and Selection of Tigecycline-Amikacin Synergy. Antimicrob Agents Chemother 52:2940-2942.
Professional Activities:
Fellow, Infectious Diseases Society of America
American Society for Microbiology Foundation Lecturer, 1998-2000
Chair - Antimicrobial Chemotherapy Division of American Society for Microbiology, 1995-1996
Editorial Board - Antimicrobial Agents and Chemotherapy, 1994-2011
Editorial Board – Microbial Drug Resistance, 2009-2012
Editor – Clinical Microbiology Reviews, 2005-2010
Ad hoc Reviewer –Clinical Microbiology and Infection, Gene, Journal of Antimicrobial Chemotherapy, Journal of Clinical Microbiology, Canadian Journal of Microbiology, European Journal of Epidemiology; Diagnostic Microbiology and Infectious Disease, Clinical Infectious Diseases
External Reviewer of the Research Center for Pathogenic Fungi and Microbial
Toxicoses, Chiba University, Chiba, Japan, 2000
Reviewer – Department of Health & Human Services, Food and Drug Administration RFA-CVM-00-1 "Research Studies on Microbiological Hazards Associated with the Food Animal Production Environment", 2000
Reviewer – Centers for Disease Control, Antimicrobial Resistance Special Emphasis Group, 2001
Reviewer – Biotechnology and Biological Sciences Research Council, UK
Reviewer – CIVR - Comitato di Indirizzo per la Valutazione della Ricerca, Italy
Reviewer – National Health & Medical Research Council, Australia
Faculty member, Faculty of 1000 Biology, 2006-2008