Nancy D. Hanson, Ph.D.
Appointment(s) and Titles:
Professor of Medical Microbiology and Immunology
Professor of Pediatrics
Director of Molecular Biology, Center for Research in Anti-Infectives and Biotechnology
Education:
BS: University of Texas, Permian Basin
MA: University of Nebraska at Omaha
PhD: University of Nebraska Medical Center, Eppley Cancer Institute
Research Interests:
Our laboratory is interested in the molecular mechanisms of antibiotic resistance, both chromosomal and plasmid-mediated; especially mechanisms involved in the regulation of gene expression required for AmpC-mediated resistance. Our laboratory is also interested in the mechanisms involved in the emergence of Pseudomonas aeruginosa resistance associated with cystic fibrosis patients. Our laboratory is also actively involved in the development of PCR-based techniques for the molecular detection of genes encoding extended-spectrum beta-lactamases, plasmid-mediated AmpC beta-lactamases, and carbapenemases in clinical isolates.
Selected Publications:
Hanson, N.D. and C.C. Sandeers, 1999. Regulation of Inducible AmpC-Beta- Lactamase Expression Among Enterobacteriaceae. Current Pharmaceutical Design 5:881-894.
Schmidtke, A. J. and N. D. Hanson. 2008. The Role ampD Homologs Play in the Overproduction of AmpC in Clinical Isolates of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 52:3922-3927
Hanson, N. D., E. S. Moland, S G. Hong, K. Propst, D. Novak, and S. J. Cavalieri. 2008 Surveillance of community-based reservoirs real the co-production of a CMY-2 AmpC β-lactamase and a CTX-M-14 extended spectrum β-lactamase in isolates of Klebsiella pneumoniae and Escherichia coli. Antimicrobial Agents and Chemotherapy. 52:3814-3816
Wolter, D.J., D. Acquazzino, R.V. Goering, P. Sammut, N. Khalaf, and N. D. Hanson. 2008. Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy. Clinical Infectious Disease. 46: 46:e137-141
Hanson, N. D., A. Hossain, L. Buck, E. S. Moland, and K.S. Thomson. 2006. The First Occurrence of a Pseudomonas aeruginosa in the United States Producing an IMP Metallo-β-lactamase, IMP-18. Antimicrobial Agents and Chemotherapy 50:2272-2273.
Schmidtke, A. J. and N. D. Hanson. 2006. A Model System to Evaluate the Effect of ampD Mutations on AmpC-mediated β-lactam Resistance. Antimicrobial Agents and Chemotherapy. 50:2030-2037.
Pitout, J. D.D., A. Hossain, and N.D. Hanson. 2004. Phenotypic and molecular detection of CTX-M-β-lactamases produced by Escherichia coli and Klebsiella spp. Journal of Clinical Microbiology. 42:5715-5721.
Reisbig, M.D. and N. D. Hanson. 2004. Promoter sequences necessary for high level expression of the plasmid-associated ampC β-lactamase gene, blaMIR-1. Antimicrobial Agents and Chemotherapy. 48:4177-4182.
Abdalhamid, B., J. D. D. Pitout, and N. D. Hanson. 2004. Community Onset Disease Caused by Citrobacter freundii Producing A Novel CTX-M b-lactamase, CTX-M-30, in Canada. Antimicrobial Agents and Chemotherapy. Antimicrobial Agents and Chemotherapy. 48:4435-4437.
Hossain, A., M.D. Reisbig, and N.D. Hanson. 2004. Plasmid-encoded functions compensate for the biological cost of AmpC over-expression in a clinical isolate of Salmonella typhimurium. Journal of Antimicrobial Chemotherapy. 53:964-970
Reisbig, M.D., A. Hossain, and N.D. Hanson . 2003. Factors Influencing Gene Expression and Resistance for Gram-Negative Organisms Expressing Plasmid-Encoded ampC genes of Enterobacter Origin. J. Antimicrobial Chemotherapy. 51:1141-1151.
Perez-Perez, F. J. and N.D.Hanson. 2002. Detection of Plasmid-Mediated AmpC b-Lactamase Genes in Clinical Isolates by Using Multiplex PCR. J. Clinical Microbiol. 40:2153-2162.
Hanson, N. D. 2003. AmpC β-lactamases: What do we need to know for the future? Journal of Antimicrobial Chemotherapy. 52:2-4.
Links:
Center for Research in Anti-Infectives & Biotechnology
Nancy Hanson Profile