The primary focus of the research in Dr. Gelineau-van Waes' laboratory is the study of birth defects. Molecular biology, proteomics, and metabolomics approaches are used to identify the underlying mechanisms that lead to placental abnormalities and and embryonic/fetal malformations following gestational exposure to pharmaceuticals (anticonvulsant drugs, immunosuppressant drugs) or environmental teratogens (arsenic, mycotoxins). Another component of her research program focuses on gene-nutrient-environment interactions during pregnancy, and the role of maternal folate supplementation in the prevention of specific types of birth defects (ie. neural tube defects, craniofacial malformations, and congenital heart defects).
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