Education & Research

Research

Neurophysiology and Neuropharmacology of Epilepsy

Epilepsy affects approximately 1-2% of the population worldwide and almost 3 million people in the United States of America. Although basic and clinical research has provided an enormous amount of data on the development of epilepsy and the evolution and progression of individual seizure episodes, a third of patients with epilepsy have seizures that do not respond to anticonvulsant drugs. Furthermore, epilepsy is often associated with co-morbidities or additional disorders including, but not limited to, cognitive and psychiatric disorders.
The hippocampus is a brain structure involved in learning and memory. Our laboratory examines hippocampal function during normal and pathologic conditions young and adult mice. We use a mouse model of to study two related but distinct focuses:

1) Discerning the role of natural neuronal population rhythms in the development and expression of epileptiform activity.
2) Investigating the role of ion channels of the mitochondrial inner membrane in pathological processes and in potential neuroprotective strategies.

The techniques used in the laboratory include electrophysiology (multi-electrode array, whole-cell patch clamp, single channel patch-clamp), immunohistochemisty and behavioral studies.

Publications

To view publications by Tim Simeone, click here...