Dale R. Bergren, PhD
Dale R. Bergren, PhD

Dale R. Bergren, PhD

School of Medicine


  • Pulmonary physiology and pharmacology, neural control of the airways

Academic Appointments


  • Biomedical Sciences


  • Professor

Teaching Activity

  • BMS 404 Course Direcctor and primary instructor
  • EKG laboratory instructor
  • IDC 203 Respiratory Systems Course Director 2001-2016
  • Lecturer in Behavior Medicien
  • Lecturer in Endocrine Systems
  • Lecturer in PHR 430 Immunopharmacology
  • Lecturer Renal Systems
  • Primary lecturer in Respiratory Systems course


Name:                                                                          Dale Robert Bergren
Birth date:                                                       September 7, 1951
Birthplace:                                                       Tombstone, Arizona
Citizenship:                                                     United States
Business Address:                             
Department of Biomedical Sciences
School of Medicine
Creighton University
2500 California Plaza
Omaha, NE  68178
Telephone Number:                                                    (402) 280-2845 (office)
                                                                        (402) 280-2690 (FAX)
            e-mail                                                  dbergren@creighton.edu
Home Address:                                   13031 Frances St.
                                                            Omaha NE 68144

Publications and Presentations


  • Anti-anaphylactic action of nordihydroguaiaretic acid in antigen sensitized guinea pigs.
    Bergren DR, Valentine JL.
    Respir Physiol Neurobiol. 2016 Dec;234:26-31. doi: 10.1016/j.resp.2016.09.003, Respiration Physiology, 2016 Dec;234:26-31. doi: 10.1016/j.resp.2016.09.003, 6, 2016
  • Pavuluri S., Hanus, V., Bergren, DR. 2013. Airway plasticity after extended mainline tobacco smoke exposure in ovalbumin sensitized guinea pigs. Respiratory Physiology & Neurobiology 189: 639– 645., Respiration Physiology, 189, 639-645, 2013
  • Bergren, D.R. and M.S. Rendell. Depressed ventilatory reflexes after capsaicin challenge in streptozotocin-treated rats., Life Science Research, 75 (17), 2103 - 2116, 2004
  • Tobacco smoke exposure and bombesin-like peptides in guinea pigs., Peptides, 23(5), : 919-26, 2002
  • Enhanced lung C-fiber responsiveness in sensitized adult guinea pigs exposed to chronic tobacco smoke., Journal of Applied Physiology, 91, 1645-1654, 2001
  • Bergren. D.R. Enhanced lung C-fiber reactivity in sensitized guinea pigs exposed to chronic tobacco smoke exposure. Journal of Applied Physiology . Accepted for publication 4-2001., Journal of Applied Physiology, 2001
  • Bergren, D.R. Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs. J. Appl. Physiol. 90: 695-704, 2001., Journal of Applied Physiology, 90, 695-704, 2001
  • Bergren, D.R. Chronic tobacco smoke exposure increases cough to capsaicin in awake guinea pigs. Respiration Physiology 126: 127-140, 2001., Respiration Physiology, 126, 127-140, 2001
  • Anesthesia increases airway responsiveness to methacholine. Horiba, M, Townley R.G. and Bergen, D.R. In revision Repiratory Physiology and Neurobiology
  • Bergen, D.R. and Rendell M.S. Depresssed ventilatory reflexes after capsaicin challenge in streptoxotocin-treated rats. Life Sciences


  • Lung C-fiber activation by substance P, capsaicin and bradykinin in guinea pigs., American Journal of Respiratory and Critical Care Medicine, 167, A708, 2003
  • FASEB Journal 13 (5) : A367, Not Applicable, 1999
  • Bergren, D.R. Lung C-fiber activation by substance P, capsaicin and bradykinin in guinea pigs. American Journal of Respiratory and Critical Care Medicine: 167 (7), A708, 2003.


  • Welcome and Introduction to the 2004 Annual Meeting of the Nebraska Physiology Society as President of the Society, 2004
  • Mechanism of substance P activation of C-fibers in guinea pigs, 2004
  • Lung C-fiber Activation By Substance P, Capsaicin and Bradykinin in Guinea Pigs. Mini-Symposium at the International Conference of the American Thoracic Society, Seattle, WA, 2003
  • Effect of TRFK-5 on airway responsiveness in ovalbumin-sensitized guinea pigs chronically exposed to tobacco smoke., 2002
  • Bergren, D.R. Airway C-fiber reactivity after chronic tobacco smoke exposure. The FASEB Journal 14(4), A654, 2001., 2001
  • Experimental Biology 99, 1999

Research and Scholarship

Research and Scholarship Interests

  • Pulmonology, Asthma
    Pulmonary fibrosis

Current Research Projects

  • Neuronal control of the airway
    Mechanism of astham, emphysema and pulmonary fibrosis

Grant Funding Received

  • Mast cells involvement in the cascade of extracellular matrix formation in idiopathic pulmonary fibrosis
  • Combined pulmonary fibrosis and emphysema syndrome resulting from tobacco smoke

Awards and Honors

  • Golden Apple Awards, Creighton University Second Year Medical Class, 2016
  • Nebraska Cancer and Smoking: One PI and One Collaborative Investigator, 1999