Kristen M. Drescher, PhD
Kristen M. Drescher, PhD

Kristen M. Drescher, PhD

Professor
School of Medicine

Academic Appointments

Department

  • Med. Microbiology & Immunology

Position

  • Professor

Biography

Examples of the most recent publications can be found at this PubMed link.

Education

  • University of New Hampshire,B.S.,1979-1983
  • University of Lowell,M.S.,1/88 - 8/90
  • Johns Hopkins University,Ph.D.,9/90-6/95

Publications and Presentations

Articles

  • Drescher KM, von Herrath M, Tracy S. Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine, Rev Med Virol, 25, 2015
  • Smithee S, Tracy S, Drescher KM, Pitz LA, McDonald T. A novel, broadly applicable approach to isolation of fungi in diverse growth media, J Microbiol Methods, 105, 155-61, 2014
  • Lynch HT, Drescher K, Knezetic J, Lanspa S. Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review, Current Treatment Options in Oncology, 15, 429-442, 2014
  • 9. “Lynch Syndrome as a Model for Identification of Hereditary High-Risk Patients” by Lynch HT, Drescher KM, Sharma P, Snyder C., Lynch JF, Knezetic J., Mitchins M, Silberstein P, and Lanspa S. in Cancers of the Colon and Rectum: A Multidisciplinary Approach to Diagnosis and Management. Benson, A, Chakravarthy A, Hamilton S, Sigurdson E, and Thomas C. (eds). Demos Medical 2013, Not Applicable, 2013
  • 4. Hu G, Drescher KM, Chen XM. Exosomal miRNAs: Biological Properties and Therapeutic Potential. Front Genet 2012 ;3:56. Epub 2012 Apr 20, Fronters in Genetics, 3, 56, 2012
  • McDonald T, Drescher KM, Weber A, Tracy S. Creatinine inhibits bacterial replication. J Antibiot (Tokyo),. 2012: Feb 1, J Antibiotics, 1-4, 2012
  • Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 Targets Transcriptional Corepressor SMRT and Modulates NF-kappaB-Regulated Transactivation of Interleukin-8 Gene. PLoS One, 2012; 7: e30772, Not Applicable, 7, 2012
  • Tracy S, Drescher KM, Chapman NM. Enteroviruses and type 1 diabetes. Diabetes Metab Res Rev, 2011; 27: 820-3, Not Applicable, 27, 2011
  • Leland KM, McDonald TL, Drescher KM. Effect of creatine, creatinine, and creatine ethyl ester on TLR expression in macrophages. International Immunopharmacology, 2011; 11:1341-1347, Not Applicable, 11, 2011
  • 2. Drescher KM and Tracy S. Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions, Annals of New York Academy of Science, 1103, 152-156, 2007
  • Tracy S and Drescher KM. Coxsackievirus infections and NOD mice: Relevant models of protection from, and induction of, Type 1 Diabetes., Annals of New York Academy of Science, 1103, 2007
  • Drescher KM and Tracy SM (2007) Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination, Virology, 359, 2007
  • Immunology for Medical Students: T Cell Development, Not Applicable, 2006
  • Kanno T, Kim K, Kono K, Drescher KM, Chapman NM, Tracy SM (2006). Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency. J Virol 80: 5637-5643., Journal of Virology, 80, 5637-5643, 2006
  • Tracy S, Chapman NM, Drescher KM, Tapprich W. Evolution of virulence in picornaviruses. Current Topics in Microbiology and Immunology,, Not Applicable, 2005, 185-205, 2005
  • Drescher, KM and Lynch HT. Tumor infiltrating lymphocytes (TILs): Lessons learned in 30 years of study, Clinical and Applied Immunology Reviews, 5 (3), 149-166, 2005
  • Lee CK, Kono K, Haas E, Kim KS, Drescher KM, Chapman NM, Tracy S (2005). Characterization of an infectious cDNA copy of the genome of a naturally-occurring, avirulent coxsackievirus B3 clinical isolate., Journal of General Virology, 86, 197-210, 2004
  • Drescher KM, Kono K, Bopegamage S, Carson SD, Tracy S (2004). Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: Insulitis determines susceptibility of pancreatic islets to virus infection., Virology, 329, 381-394, 2004
  • Drescher KM, Kocakova P, Chapman NM, Tracy SM (2004). CVB-based vaccines alter immune responses to self in virus-infected mice., 12th International Congress of Immunology, 341-344, 2004
  • Drescher KM, Kono K, Bopemagamage S, Carson SD, Tracy S Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection, Virology, in press, 2004
  • Pavelko, K.D., Howe, C.L., Drescher, K.M., Gamez, J.D., Johnson, A.J., Wei, T., Ransohoff, R.M., Rodriguez, M. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury, Journal of Neuroscience, 23(2), 481-492, 2003
  • Toward testing the hypothesis that Group B Coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence; S. Tracy, K.M. Drescher, N.M. Chapman, K.S.Kim, S.D. Carson, S. Pirruccello, P.H. Lane, J.R. Romero, J.S. Leser, Journal of Virology, 76, 12097-12111, 2002
  • Drescher KM, Zoecklein LJ, Rodriguez M. ICAM-1 is critical for protection from TMEV-induced brain pathology but not demyelination, Journal of Neurovirology, 8, 425-458, 2002
  • ”T-Cell ” Immunology for Medical Students. Nairn and Helbert. C.V. Mosby Co, Not Applicable, 2002
  • 26th International Congress of Internal Medicine VACCINATION OF YOUNG NONOBESE DIABETIC (NOD) MICE WITH GROUP B COXSACKIEVIRUS LOWERS TYPE 1 DIABETES INCIDENCE. Steven Tracy1, Nora M. Chapman1, Kyung-Soo Kim1, Kristen M. Drescher2, Pascale H. Lane3, Samuel Pirruccello1, J. Smith Leser1., Not Applicable, 2002
  • Pavelko, K.D.*, Drescher, K.M.*, McGavern, D.B., David, C.S., and Rodriguez, M. HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis. Molecular and Cellular Neuroscience 15:495-509. *Both authors contributed equally to this manuscript., Molecular and Cellular Neuroscience, 495-509, 2000
  • Drescher, K.M., Zoecklein, L.J., Pavelko, K.D., Rivera-Quinones, C., Hollenbaugh, D. and Rodriguez, M. (2000) CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis. Brain Pathology 9:1-15., Brain Pathology, 1-15, 2000
  • 13. Drescher, K.M., Johnston, S.L., Hogancamp, W., David, C.S., Rimm, I.J., Wettstein, P.J., and Rodriguez, M. Vb8+ T cells protect from demyelinating disease in a viral model of multiple sclerosis. International Immunology 12: 271-280., International Immunology, 271-280, 2000
  • Das, P., Drescher, K.M., Bradley, D.S., Rodriguez, M. and David, C.S. (2000) Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis. Human Immunol. 61: 279-289., Human Immunology, 279-289, 2000
  • CD40L is critical for protection from demyelinating disease and development of spontaneous remyelination in a mouse model of multiple sclerosis: Brain Pathology, Not Applicable, 1999
  • Vb8+T cells protect from demyelinating disease in a viral model of multiple sclerosis: International Immunology, Not Applicable, 1999
  • TGF-b2 reduces demyelination, virus antigen expression, and macrophage recruitment in a viral model of multiple sclerosis; Journal of Immunology, Not Applicable, 1999
  • Complementation betweeen specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis; Human Immunology, Not Applicable, 1999
  • Drescher, K.M., L.J. Zoecklein, and M. Rodriguez. ICAM-1 is crucial to protection from TMEV-induced neuronal damage but not demyelination. Journal of Neurovirology. Submitted.
  • Tracy, S., K.M. Drescher, N.M. Chapman, K.-S. Kim, S.D. Carson, S. Pirruccello, P.H. Lane, J.R. Romero, and J.S. Leser. Toward testing the hypothesis that Group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence. Journal of Virology, Submitted.
  • Pavelko, K.D., C.L. Howe, K.M. Drescher, J.D. Gamez, A.J. Johnson, T. Wei, R.M. Ransohoff, M. Rodriguez. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. Cellular and Molecular Neuroscience, Submitted.

Publications

  • Neuregulin-1 is upregulated in the sciatic nerve following infection with TMEV. KM Drescher, J Sunde, SM Tracy, International Congress of Virology, 11, v212, 2005
  • Group B coxsackievirus infections in NOD mice: towards clarifying the role of enteroviruses in human type 1 diabetes onset, International Congress of Virology, 11, v173, 2005
  • E-selectin is expressed in coxsackievirus B3 myocarditis; JSM Yeh, S Tracy, KM Drescher, J Sunde, K Kono, N Chapman, JJ Boyle, T Hussell, C Sennoga, RJ Eckersley, MJ Blomley, DO Haskard, P Nihoyannopouloss, J American College of Cardiology, 2005
  • Use of CVB-based Vaccines to Modify an Immune-Response to Self Kristen M. Drescher, Paulina Kocakova, Nora M. Chapman, and Steven M. Tracy, Abstract Book, ACTRIMS, 2004
  • Inhibition of Cellular Immune Response to Self-Epitopes in TMEV-Infected Mice Kristen M. Drescher, Paulina Kocakova, Nora M. Chapman, and Steven M. Tracy, Abstract Book, Intl. Congress of Immunology, 2004
  • SM Tracy, KM Drescher, K Kono, SD Carson, S Bopegamage; Coxsackievirus replicates in islets of old NOD mice and initiates diabetes, Seventh International Symposium on Positive Stranded RNA Viruses, 1, 2004
  • P. Kocakova and K. Drescher; C3 is required for efficient clearance of virus from brains of TMEV-infected mice, FASEB Journal, 2004

Editing and Reviews

  • Lynch HT, Lanspa SJ, Snyder CL, Drescher KM. Microsatellite instability, disease-free survival and role of tumour infiltrating lymphocytes (Invited editorial on 'Predictors of disease-free survival in colorectal cancer with microsatellite instability: An AEGO study), European Journal of Cancer, 51, 922-924, 2015

Presentations

  • Presentation for the Health Sciences Educator Development Program How to Improve Your Teaching: Insight From the Evaluation Committee, 2015
  • Drescher, KM and Tracy, SM Injection of the Sciatic Nerve with Theiler’s Virus: A Model of Virus-Induced Peripheral Demyelination; Positive Strand Meeting; Washington DC (poster), 2007
  • Tracy, SM and Drescher, KM COXSACKIEVIRUS AND NOD MICE: RELEVANT MODELS OF PROTECTION FROM, AND INDUCTION OF, TYPE 1 DIABETES, 2006
  • Drescher, KM and Tracy, SM Establishment of a model to examine the events involved in the development of virus-induced demyelinating lesions. NY Acad Sciences, Animal Models of MS and TID, San Franscisco, 2006
  • National Multiple Sclerosis Society - Nebraska Chapter; TRENDS meeting; Roundtable Discussion on Research, 2006
  • Drescher KM and Tracy S Coxsackie B virus replication in pancreatic islets: virus associates with the four major islet cell types, not merely beta cells American Society of Virology, Madison, WI., 2006
  • 6. Tracy, S.M., Drescher, K.M., Jackson, J.D., Sanderson, S Vaccinating NOD mice against CVB-induced rapid T1D onset: type-specific immunity is not required to lower T1D incidence American Society of Virology, Madison, WI., 2006
  • Neuregulins in the peripheral nervous system in virus infections and autoimmune disease, 2006
  • Role of C3 in a model of virus-induced encephalitis, 2006
  • Impact of C3 deletion in a mouse model of virus induced demyelinating disease UNMC Department of Cell Biology and Genetics, 2006
  • Birth of a successful women in medicine and science program in a private, Jesuit medical school; R.E. Sonnino, M. Gentry-Nielsen, K.M. Drescher, M. Schofield, A. Chatterjee; AAMC Meeting, 2005
  • Neuregulin is upregulated in the sciatic nerve following infection with TMEV; KM Drescher, A Heller, S Tracy; International Congress of Virology, 2005
  • Group B Coxsackievirus infections in NOD mice: Towards clarifying a role of enteroviruses in human type 1 diabetes onset, S, Tracy and K. Drescher, International Congress of Virology, 2005
  • American College of Cardiology, 2005
  • Hounsfield Lecture (Imperial College, London) Developing A Novel Ultrasound Method Of Imaging Molecular Activities Dr J Yeh Dr C Sennoga Prof M Blomley Mr P Muckett Dr R Eckersley Prof S Tracy Dr K Drescher Dr YW Li Dr C Tang Dr J Boyle Dr J Mason8 Dr S Nourshargh Prof J Seddon Prof D Haskard Dr P Nihoyannopoulos, 2005
  • America's Conference on the Treatment and Immunology of Multiple Sclerosis, 2004
  • CVB-induces diabetes in older NOD mice; SM Tracy, KM Drescher, K Kono, S Bopegamage, SD Carson, 2004
  • International Congress on Immunology, 2004
  • Coxsackie B virus replicates in islets of old NOD mice and initiates type 1 diabetes. Steven Tracy, Kristen M. Drescher, Ken Kono, Steven D. Carson, Shubhada Bopegamage; Seventh International Symposium on positive-strand RNA viruses; San Francisco, CA, 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice; Federation of the American Society of Experimental Biology, 2004
  • Cary M. Wolter,Jill R. Fuhrman, and Kristen M. Drescher Localization of matrix metalloproteinases (MMPs) in the brains of TMEV-infected mice Midwest Medical Student Research Forum (poster), 2004
  • Oshunleti, O. and Drescher, K.M. Use of CVB chimeric viruses as vaccine vectors in an animal model of multiple sclerosis - National Medical Fellowship Program, 2004
  • Paula Kocakova and Kristen M. Drescher C3 is required for efficient clearance of virus from the brains of TMEV-infected mice, Midwest Medical Student Research Forum, 2004
  • Immunology Group - Use of CVB chimerae as vaccines in a model of multiple sclerosis, 2002
  • Johnson, T.D., Marsh, L.B., Ray, T., Drescher, K.M. The relative contribution of B cells and complement in protection of the brain from Theiler's murine encephalomyelitis virus. Minority summer student poster session, 2002
  • Tracy et al, X!!th International COngress of Virology, 2002
  • Modulation of activin/inhibin mRNA levels following TMEV infection XIIth International Congress of Virology (Paris, France), 2002
  • Theiler's Virus model of multiple sclerosis, 2002
  • Ukpo,O.C., S.E. Hopkins and K.M. Drescher. Identification of apoptotic cells in the brains and spinal cords of TMEV-infected mice. Minority Summer Student Research Forum (Poster), 2001
  • Hopkins, S.E., O.C. Ukpo, and K.M. Drescher. Apoptosis in the brains of TMEV-infected C57BL6/J and B10.Q mice. Minority High School Student Research Forum (Poster)., 2001
  • Texas A & M University - Neuroscience Seminar Series, 2001
  • University of Nebraska Medical Center - Department of Cell Biology and Anatomy, 2001
  • Cooper, D.M. and Drescher, K.M. - Regional ASM Meeting - oral presentation, 2001
  • University of Nebraska Medical Center - Immunology Interest Group, 2001
  • Cooper, D.C. and Drescher, K.D. Midwest Student Research Forum - poster, 2001
  • Cooper, D.M. and Drescher, K.D. - Regional AAAS Meeting - poster, 2000
  • Flores, N., Cooper, D.M. and Drescher, K.M. - Minority summer student poster session, 2000
  • 10/22/99;VA Hospital;"Expression of the HLA-DR3 Transgene reduces the severity of demyelination in a viral model of multiple sclerosis", 1999

Research and Scholarship

Research and Scholarship Interests

  • Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS) in humans. Patients with MS normally experience a chronic progressive loss of motor and/or sensory functions. The origin of MS is unknown, although some investigators have postulated than an environmental agent (i.e. a virus or bacteria) may trigger the disease. My laboratory utilizes a mouse model of virus-induced demyelination (Theiler's murine encephalomyelitis virus) to study immune factors involved in the development of pathology and clinical disease.

Current Research Projects

Awards and Honors

  • Provisional - MODIFIED TRIZOL METHODOLOGY FOR RNA ISOLATION FROM RNASE-RICH TISSUES (Patent No: 60/934517), 2007
  • National Award, NY Academy of Sciences, 2006