Diane M. Cullen, PhD
Diane M. Cullen, PhD

Diane M. Cullen, PhD

Professor
School of Medicine

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Professor

Secondary Appointment

  • Medicine

Teaching Activity

  • Course Director for Medical anatomy and MusculoSkeletal Integument courses

Education

  • State University of New York,B.S.,1972-76
  • Western Illinois University,M.S.,1976-77
  • University of Wisconsin-Madison,Ph.D.,1983-89

Publications and Presentations

Articles


  • Huggett Kathryn N.,  White Michael D., Knoop Floyd C., Eno Cassie A., Cullen Diane M. Team-Based Learning in Anatomy: Promoting Active Learning and Professionalism. Medical Science Educator   26:5-6.
     , 2016
  • Huggett Kathryn N.,  White Michael D., Knoop Floyd C., Eno Cassie A., Cullen Diane M. Lightning Rounds: Promoting Active Learning and Retrieval Practice in Anatomy Labs. Medical Science Educator 26:9-10, 2016
  • Smith BJ, Bu SY, Wang Y, Rendina E, Lim YF, Marlow D, Clarke SL, Cullen DM and Lucas EA. A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat., Bone, 58, 151-159, 2014

  • Meyer LA, Johnson MG, Cullen DM, Vivanco JF, Blank RD, Ploeg HL, Smith EL. Combined exposure to big endothelin-1 and mechanical loading in bovine sternal cores promotes osteogenesis. Bone. 85:115-122
     , 2014
  • Vivanco J, Garcia S, Ploeg HL, Alvarez G, Cullen D, Smith EL. Apparent elastic modulus of ex vivo trabecular bovine bone increases with dynamic loading Proc Inst Mech Eng H , 227: 904-912, 2013
  • Ma D, Li Y, Hackfort B, Zhao Y, Xiao J, Swanson PC, Lappe J, Xiao P, Cullen D, Akhter M, Recker R, Xiao GG. Smoke-induced signal molecules in bone marrow cells from altered low-density lipoprotein receptor-related protein 5 mice. J Proteome Res 11(7):3548-60., 2012
  • Palmer VL, Kassmeier MD, Willcockson J, Akhter MP, Cullen DM,  Swanson P. N-acetylcysteine increases the frequency of bone marrow pro-B/pre-B cells, but does not reverse cigarette smoking-induced loss of this subset.  PLoS ONE 6:9, 2011
  • Jepsen KJ, Centi A, Duarte GF, Galloway K, Goldman H, Hampson N, Lappe JM, Cullen DM, Greeves J, Izard R, Nindl BC, Kraemer WJ. Biological constraints that limit compensation of a common skeletal trait variant lead to inequivalence of tibial function among healthy young adults. J Bone Miner Res  26:2872-2885, 2011
  • Akhter MP, Alvarez GK, Cullen DM, Recker RR. Disuse-related decline in trabecular bone structure. Biomech Model Mechanobiol 10:423-429, 2011
  • Manolides AS, Cullen DM, Akhter MP. Effects of glucocorticoid treatment on bone strength. J Bone Miner Metab.  28(5):532-9, 2010
  • Fusby JS, Kassmeier MD,. Palmer VL, Perry GA, Anderson DK, Hackfort BT, Alvarez GK, Cullen DM, Akhter MP, Swanson PC. Cigarette smoke-induced effects on bone marrow B cell subsets and CD4+:CD8+ T cell ratio are reversed by smoking cessation. Inhalation Toxicology 22: 785-96, 2010
  • Hein CD, Liu XM, Chen F, Cullen DM, Wang D. The synthesis of a multiblock osteotropic polyrotaxane by copper(I)-catalyzed huisgen 1,3-dipolar cycloaddition. Macromol Biosci 10:1544-1556, 2010
  • Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA. Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Int J Cancer. 125(2):276-85, 2009
  • Heaney RP, Horst RL, Cullen DM, Armas LA. Vitamin D3 distribution and status in the body. J Am Coll Nutr 28:252-256, 2009
  • Lee Y, Schmid MJ, Marx DB, Beatty MW, Cullen DM, Collins ME, Reinhardt RA.The effect of local simvastatin delivery strategies on mandibular bone formation in vivo. Biomaterials. 2008 12:1940-9, 2008
  • Liu XM, Wiswall AT, Rutledge JE, Akhter MP , Cullen DM, Reinhardt RA, Wang D, Osteotropic b-cyclodextrin for local bone regeneration. Biomaterials 29:1686-92, 2008
  • Lappe J., Cullen D., Recker R., and Thompson K. Calcium and Vitamin D Supplementation Decreases Incidence of Stress Fractures in Female Navy Recruits. Journal of Bone and Mineral Research, 23:741-49, 2008
  • Kuruvilla S, Cullen DM, Akhter  MP. Site Specific Bone Adaptation Response to Mechanical Loading. J-Musculoskelet-Neuronal-Interact 8(1):71-78, 2008
  • Bradley JD, Cleverly DG, Burns AM, Helm NB, Schmid MJ, Marx DB, Cullen DM, Reinhardt RA.  Cyclooxygenase-2 inhibitor reduces simvastatin induced bone morphogenetic protein-2 and bone formation in vivo J Periodont Res 42: 267-27, 2008
  • Wittel UA, Singh AP, Henley BJ, Andrianifahanana M, Akhter MP, Cullen DM, Batra SK. Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas. Pancreas. 33(4):364-70, 2006
  • Wittel UA,. Pandey KK, Johansson SL, Cullen DM, Akhter MP, Brand RE, Prokopczyk B, and. Batra SK Chronic Pancreatic Inflammation Induced By Environmental Tobacco Smoke Inhalation In Rats., Am J Gastroenterol, 101 (1), 148-159, 2006
  • Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, Kharode Y, Sauter L, Babij P, Brown EL, Akhter MP, Johnson ML, Recker RR, Komm BS, Bex FJ. Wnt/-catenin signaling is a normal physiological response to mechanical loading in bone. J Biological Chem. 281: 31720 – 31728, 2006
  • Akhter MP, Cullen DM, Pan L. Bone biomechanical properties in EP4 knock-out mice. Calcified Tissue International  78(6): 357-62, 2006
  • Cai J, Zhao Y, Glasier J, Cullen D, Barnes S, Turner C and Weaver C. Comparative effect of soy protein, soy isoflavones and 17b-estradiol on bone metabolism in adult ovariectomized rats., J Bone Miner Res, 20, 828-839, 2005
  • Stein DM, Lee Y, Schmid MJ, Killpack B, Genrich MA, Narayana N, Marx DB, Cullen DM, Reinhardt RA.  Local simvastatin effects on mandibular bone growth and inflammation J Peridontol; 76: 1861-1870, 2005
  • Smith, RT, Cullen, DNM. Chapter 31 Osteoporosis and Exercise in Clinical Exercise Physiology: Application and Physiological Principles, Ed: LeMura and von Duvillard: Lippencott, Williams & Wilkins, Philadelphia, PA g 485-501, 2004
  • Rubin C., Recker R., Cullen D, Ryaby J, McCabe J, McLeod K Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety, J Bone Miner Res, 19, 343-351, 2004
  • Akhter M P, Wells DJ,  Short SJ, Cullen DM, Johnson M L, Haynatzki GR, Babij P, Allen K M, Yaworsky P J, Bex F, Recker RR. Bone biomechanical properties in LRP5 mutant mice. Bone 35, 162-169, 2004
  • Akhter MP, Otero, JK, Iwaniec UT, Cullen DM, Haynatzki GR, Recker RR. Differences in vertebral structure and strength of inbred female mouse strains. J Musculoskel Neuron Interact. 4:33-40, 2004
  • Akhter MP, Iwaniec UT, Haynatzki GR, Fung YK, Cullen DM, and Recker RR. Effects of Nicotine on Bone Mass and Strength in Aged Female Rats. J Orth. Res 21:14-19, 2003
  • Cullen DM Summary - Bone growth and exercise in children. J Musculoskel Neuron Interact 3(4):356, 2003
  • Iwaniec U.T., Haynatzki,G.R., Fung Y.K., Akhter M.P., Haven M.C., and Cullen D.M., Effects of Nicotine on Bone and Calciotropic Hormones in Aged Ovariectomized Rats, J Musculoskel Neuron Interact, J Musculoskel Neuron Interact, 2, 469-478, 2002
  • Akhter, MP, Cullen, DM, Recker, RR. Bone adaptation to sham and bending stimuli in mice, J Clinical Densitometry, 5, 207-216, 2002
  • Iwaniec U.T. , Samnegård E., Cullen D.M., and Kimmel D.B., Maintenance of cancellous bone in ovariectomized, human parathyroid hormone (1-84) treated rats by estrogen, risedronate, or reduced hPTH, Bone, 29, 352-360, 2001
  • Cullen DM, Smith RT, Akhter M.P. Bone Loading Response Varies With Strain Magnitude And Cycle Number, Journal of Applied Physiology, 91, 1971-1976, 2001
  • Akhter MP, Cullen DM, Gong G, Recker RR. Biomechanical Properties in Prostaglandin EP1 and EP2 Knock-out Mice, Bone, 29, 121-125, 2001
  • Samnegård E., Cullen DM., Akhter MP., Kimmel DB. No effect of verapamil on the local bone response to in vivo mechanical loading, Journal of Orthopaedic Research, 19, 328-336, 2001
  • Iwaniec U.T., Fung Y.K., Akhter M.P., Haven M.C., S. Nespor S., Haynatzki G.R., and Cullen D.M. Effects of nicotine on bone mass, turnover, and strength in adult female rats., Calcif Tissue Int, 68, 358-364, 2001
  • Samnegård E., Cullen DM., Akhter MP., Kimmel DB. No effect of verapamil on the local bone response to in vivo mechanical loading., J. Ortho. Res., 19, 328-336, 2001
  • Samnegård E., Iwaniec U.T., Cullen D.M., Kimmel D.B., Recker R.R. Maintenance of Cortical Bone in hPTH(1-84) Treated Ovariectomized Rats., Bone, 28, 251-260 , 2001
  • Cullen, D.M., U. Iwaniec, and M.J. Barger-Lux. Skeletal response to exercise and training. In: Exercise: Basic and Applied Science, edited by W. Garret and D. Kirkendall. Baltimore: Lippincott Williams and Wilkins, Philadelphia, PA , p. 227-237., 2000
  • Akhter, M.P., U.T. Iwaniec, M.A. Covey, D.M. Cullen, D.B. Kimmel, and R.R. Recker. Genetic variations in bone density, histomorphometry, and strength in mice., Calcif Tissue Int, 67, 337-344, 2000
  • Iwaniec UT, Fung YK, Akhter MP, Haven MC, Schmid M, Cullen DM. Effects of nicotine on bone and calcitropic hormones in growing female rats., Calcif Tissue Int, 67, 68-74, 2000
  • Cullen DM, Smith RT, Akhter M.P. Time course for bone formation with long term external mechanical loading, Journal of Applied Physiology, 88, 1943-1948, 2000
  • Pedersen, E.A., M.P. Akhter, D.M. Cullen, D.B. Kimmel, and R.R. Recker. Bone response to in vivo mechanical loading in C3H/HeJ mice., Cacified Tissue International, 65, 41-46, 1999
  • Fung, Y.K., U. Iwaniec, D.M. Cullen, M.P. Akhter, M.C. Haven, and P. Timmins. Long-term effects of nicotine on bone and calcitropic hormones in adult female rats. Pharmacology & Toxicology 85: 181-187,, 1999
  • Stout J, Eckerson J, Noonan D, Moore G, Cullen D. Effects of 8 weeks of creatine supplementation on exercise performance and fat-free weight in football players during training. Nutrition Research 19: 217-225,, 1999
  • Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR. Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tissue Int 63:442-449, 1998
  • Boppart MD, Kimmel DB, Yee JA, Cullen DM. Time course of osteoblast appearance after in vivo mechanical loading. Bone 23:409-415, 1998
  • Tang LY, Cullen DM, Yee JA, Jee WSS, Kimmel DB. Prostaglandin E2 increases the skeletal response to mechanical loading. J Bone Mineral Res 12:276-277, 1997
  • Raab-Cullen DM. In vivo bone cell histology and biochemical responses to mechanical loading. In: Biochemistry of Exercise IX, edited by RJ Maughan. Champaign, IL: Human Kinetics,  p. 543-554, 1996
  • Crenshaw TD, Raab DM, Golz DI, and Smith EL. Use of dietary Ca and P and photon absorptiometry to predict mechanical properties of bone in swine. In: Swine in Biomedical Research. Ed. ME Tumbleson Vol. 2:1085-90. Plenum Press, New York, New York, 1996
  • Drinkwater BL, Grimston SK, Raab-Cullen DM, Snow-Harter CM. ACSM position stand on osteoporosis and exercise. Med Sci Sports Exercise 27:i-vi, 1995
  • Baldwin KM, White TW, Arnaud SB, Edgerton VR, Kraemer WJ, Kram R, Raab-Cullen DM., Snow CM. Musculoskeletal adaptations to weightlessness and development of effective countermeasures. Med Sci Sports Exercise. 28:1247-1253, 1995
  • Raab-Cullen DM, Thiede MA, Petersen DN, Kimmel DB, Recker RR. Mechanical loading stimulates rapid changes in periosteal gene expression. Calif Tissue Int 55:473-478, 1994
  • Raab-Cullen D, Akhter MP, Kimmel DB, Recker RR. Periosteal bone formation is stimulated by externally induced bending strains. J Bone Mineral Res 9:1143-1152, 1994
  • Raab-Cullen D, Akhter M, Kimmel D, Recker R. Bone response to alternate day mechanical loading of the rat tibia. J Bone Mineral Res: 9:203-211, 1994
  • Lane N, Maeda H, Cullen D, Kimmel D. Cancellous bone behavior in hindlimb immobilized rats during and after Naproxen treatment. Bone and Mineral 26:43-60, 1994
  • Maeda H, Kimmel DB, Raab DM, Lane N. Musculoskeletal recovery following hindlimb immobilization in adult female rats. Bone 14:153-159, 1993
  • Tommerup LJ, Raab DM, Crenshaw TD, Checovich MM, and Smith EL. Does weight bearing exercise affect non-weight bearing bone. J Bone Mineral Res 8:1053-1058, 1993
  • Hagino H, Raab DM, Kimmel DB, Akhter MP, Recker RR. The effect of ovariectomy on bone response to in vivo external loading. J Bone Mineral Res 8:347-357, 1993
  • Akhter MP, Raab DM, Turner CH, Kimmel DB, and Recker RR. Characterization of in vivo strain in the rat tibia during external application of a four-point bending load. J Biomech 25:1241-1246, 1992
  • Marcus R, Drinkwater B, Dalsky G, Dufek J, Raab D, Slemenda C, Snow-Harter C. Osteoporosis and exercise in women. Med Sci Sports Exercise 24:S301-s307, 1992
  • Raab DM, Crenshaw TD, Kimmel DB, and Smith EL. A histomorphometric study of cortical bone activity during increased weight bearing exercise. J Bone and Mineral Res 7: 741-749, 1991
  • Turner CH, Akhter MP, Raab DM, Kimmel DB, and Recker RR. A non-invasive, in vivo model for studying strain adaptive bone modeling. Bone 12: 73-79, 1991
  • Raab DM, Crenshaw TD, Smith EL, and Thomas DP. Bone mechanical properties after exercise training in young and old rats. J Appl Physiol. 68(1):130-4, 1990
  • Thomas DP, McCormick KM, Gosselin LE, Julin CM, Raab DM, and Wanta D. Age-training interactions on cell size and vascularity in the rat heart. Excerpta Med Int Congress Series 921:943-948, 1990
  • Osness WH., Adrian M, Clark B, Hoeger W, Raab D, and Wiswell R. Functional fitness assessment for adults over 60 years. American Alliance of Health, Physical Education, Recreation and Dance. Reston, VA, 1990
  • Agre JC, Smith EL, Pierce LE, McAdam M, and Raab DM. Light resistance and stretching exercise in elderly women: Effects upon strength. Archives of Physical Med and Rehab 69:273-276, 1988
  • Raab DM, Agre JC, McAdam M, and Smith EL. Light resistance and stretching exercise in elderly women: Effects upon flexibility. Archives of Physical Med and Rehab 69:268-272, 1988
  • Smith EL, and Raab DM. Osteoporosis and physical activity. Acta Med Scand, Suppl. 711:149-156, 1987
  • Basset DR Jr, Giese MD, Nagle FJ, Ward A, Raab DM, Balke B. Aerobic requirements of overground versus treadmill running. Med Sci Sports and Exercise. 17:477-481, 1985
  • Raab DM, and Smith EL Exercise and aging effects on bone. Topics in Geriatric Rehab. 1:31-39, 1985

Publications

  • McCumber TL, Drescher K, Turturro M, Cullen DM, Mechanically-Induced Osteocyte-Th17 Cell Signaling and Subsequent Osteoclast Formation, American Society of Bone and Mineral Research ). Available at http://www.asbmr.org/education/2016-abstracts, 2016

  • Turturro ., McCumber T, Billheimer J, Cullen D. Th17 involved in inflammatory response following mechanical loading in vivo. American Society of Bone and Mineral Research ). Available at http://www.asbmr.org/education/2016-abstracts.
     , 2016
  • Peterson V.M. , Hugenroth B.J. ,Rosauer B.A. , CullenD.M. ,Akhter M.P.  Osteocyte Lacunar Characteristics as a Function of Genotype and Age in Bone Tissue American Society of Bone and Mineral Research ). Available at http://www.asbmr.org/education/2015-abstracts, 2015
  • McCumber TL, Drescher K, Cullen DM, A Novel Mechanically-Induced Osteocyte/Th17 Cell Signaling Mechanism, American Society of Bone and Mineral Research ). Available at http://www.asbmr.org/education/2015-abstracts, 2015
  • Akhter MP, Cullen DM, Danforth J, Biomechanical Analyses of Bone Tissue Damage from Fatigue Loading In Vivo. American Society of Bone and Mineral Research Houston, Tx, September, 2014 Available at http://www.asbmr.org/education/2014-abstracts, 2014
  • Hackfort BT, Akhter MP, Cullen DM. Cyclooxygenase Response to Multiple Mechanical Loads in Mice., J Bone Miner Res, 29 Suppl, 2014
  • McCumber TL, Hackfort BT, Akhter MP, Cullen DM. In Vivo Fatigue Damage in Bone Linked to Cytokine Expression, J Bone Miner Res, 29 Suppl, 2014
  • Cullen D, Alvarez G, Meyer L, Johnson M, Vivanco J, Blank R, Ploeg H, Smith E, Mechanical Loading And Big Endothelin-1 In Trabecular Bone Cores American Society of Bone and Mineral Research. J Bone Miner Res 27 (Suppl 1). Available at http://www.asbmr.org/education/2013-abstracts
     , 2013
  • Hackfort BT, Alvarez GK, Akhter MP, Cullen DM, Cox-2 is Not Essential for the Bone Formation Response to Long Term Tibial Compression in Mice. American Society of Bone and Mineral Research October 2012. Available at http://www.asbmr.org/education/2012-abstracts, 2012
  • Cullen DM,  Hackfort B, Alvarez GK,Rousch S, Stein M., Akhter M.Time Course of Bone Response to Smoke Exposure in Cortical Bone. American Society of Bone and Mineral Research October 2011. . Available at http://www.asbmr.org/education/2011-abstracts, 2011

  • Hackfort B, Alvarez GK., Akhter M. Cox-2 Inhibition Suppresses the Response to Short Term Tibial Compression in Mice. American Society of Bone and Mineral Research October 2011. Available at http://www.asbmr.org/education/2011-abstracts
     , 2011

  • Recker, RR, Cullen DM, Armas L Type 1 Diabetes Mellitus Effects on Bone: Preliminary Results of Peripheral Quantitative Computed Tomography (pQCT) Analysis. American Society of Bone and Mineral Research October 2011. Available at http://www.asbmr.org/education/2011-abstracts
     , 2011

  • Hein J, McMichen B, Stibbbe A, Negahban M, Cullen DM, Turner J, Akhter M, Poster Sessions, Mapping Tibial Surface Strains Using 3D Stereo Optical System American Society of Bone and Mineral Research October 2010, Toronto, Ontario. . Available at http://www.asbmr.org/education/2010-abstracts
     , 2010

  • Miller J, Alvarez GK,. Yee JA, Cullen DM,  Fluid Flow Activation of Osteoblasts and the Interaction of PKA and AKT MO0212, American Society of Bone and Mineral Research October 2010, Toronto, Ontario. Available at http://www.asbmr.org/education/2010-abstracts
     , 2010
  • Lappe JM, Heaney R, Davies KM, Cullen DM Magnitude and Timing of Peak Bone Mineral Accrual in Young Girls FR0010, American Society of Bone and Mineral Research October 2010, Toronto, Ontario. Available at http://www.asbmr.org/education/2010-abstracts, 2010
  • Hackfort B, Alvarez GK, Akhter M, Cullen DM,Lrp5 Receptor and PGE2 in Bone Response to Mechanical Loading MO0204, American Society of Bone and Mineral Research October 2010, Toronto, Ontario. Available at http://www.asbmr.org/education/2010-abstracts, 2010
  • Hackfort B, Alvarez G, Akhter M, Cullen D; Differential Effects of Parathyroid Hormone (PTH) and Tibial Compression on Bone Formation with Variation in Lrp5 Expression. American Society of Bone and Mineral Research October 2009, Denver Col.. Available at http://www.asbmr.org/education/2009-abstracts, 2009
  • Bryan A, Alvarez G,  Mitchell A,  Yee J,  Torgersen Z, Cullen D; Parathyroid Hormone-Related Protein (PTHrP) in the Response of Murine Osteoblasts to Pulsatile Fluid-Flow Shear Force. American Society of Bone and Mineral Research October 2009, Denver Col.. Available at http://www.asbmr.org/education/2009-abstracts, 2009

  • Stibbe A, Cullen D, Akhter M; Mechanical Strain Patterns in Tibiae. American Society of Bone and Mineral Research October 2009, Denver Col.. Available at http://www.asbmr.org/education/2009-abstracts, 2008

  • Smith B, Cullen D, Bu S, Clarke S, Rendina E, Lim Y, Lucas E. Dried Plum Alters Bone Metabolism Via a Different Mechanism than PTH. J Bone Miner. Res. 23: M341: suppl 2008.
     , 2008

  • Alvarez G, Hackfort B, Akhter M, Yee J, Cullen D. Bone Loss With Smoke Exposure and Lrp5 Expression. J Bone Miner. Res. 23: Sa459: suppl.
     , 2008
  • Akhter M, Manolides A, Cullen D, Recker R. LRP5 G171V Mutation and Tobacco Smoke Related Bone Fragility. J Bone Miner. Res. 23: M323: suppl, 2008
  • Bryan A, Cullen D, Yee J. hPTHrP 1-36 Stimulates PKA-Dependent Phosphorylation and Nuclear Translocation of β-Catenin In Neonatal Mouse Calvarial Bone Cells J Bone Miner. Res. 23: F032: suppl, 2008
  • Moen S, Hackfort B, Alvarez G, Cullen D. Bone Formation in Mice with Variations in Lrp5 Expression. J Bone Miner. Res. 23: F550: suppl, 2008
  • Hackfort B, Knierim D, Alvarez G, Cullen D, Akhter M. Bone Response to Mechanical Loads and Lrp5 Genotype. J Bone Miner. Res. 23: M020: suppl, 2008
  • Cullen DM, GK Alvarez, BT Hackfort, B McGuckin, MP Akhter. In Vivo Tibial Compression Stimulates Bone Formation. J Bone Miner. Res. 22: #2088: supp, 2007
  • Akhter MP, Cullen DM, Recker RR. LRP5 G171V Mutation and Age-Related Bone Fragility. [Plenary Poster Presentation] – J Bone Miner. Res. 22: #1146, suppl, 2007
  • Akhter MP, Cullen DM, Recker RR. LRP5 G171V mutation Protects Against Disuse-Related Trabecular Bone Fragility. [Plenary Poster Presentation] – J Bone Miner. Res. 22: #1129, suppl, 2007
  • Alvarez GK, BT Hackfort, B McGuckin, MP Akhter, DM Cullen. Lrp5 Gene Expression and Bone Turnover With Disuse. J Bone Miner. Res. 22: #1239: suppl, 2007
  • Goetz LR, Alvarez G, Akhter MP, Cullen DM. Osteocyte Apoptosis with Tobacco Smoke Exposure and Estrogen Deficiency.  J Bone Miner. Res. 21: S266, 2006
  • Akhter MP, Cullen DM, Recker RR. Tobacco Smoking Influences on Bone Mechanical Properties .  J Bone Miner. Res. 21: S228, 2006
  • Akhter MP, Cullen DM, Recker RR. LRP5 G171V Mutation and Disuse-Related Bone Structural Properties. . Plenary Poster Presentation  J Bone Miner. Res. 21: S94,, 2006
  • Lappe JM; Cullen DM.; Thompson K;  Ahlf R Calcium and vitamin d supplementation reduces incidence of stress fractures in navy recruits. Trans.53rd Ann.Meeting Orthop.Res.Soc (ORS), 2006
  • Szender JB; Currier AD; McGuckin B; Barkey ME; Cullen DM, Akhter MP, Tibial strain distribution in mice tibias Trans.53rd Ann.Meeting Orthop.Res.Soc (ORS), 2006
  • Cullen DM, Kumar R, Alvarez G, Akhter MP. Smoke Exposure Alters The Bone Response To Estrogen Deficiency. J Bone Miner. Res. 20: suppl 1:SA200, 2005
  • Lopez Franco GE, Blank R, McGuckin BL, Johnson ML, Cullen DM, Recker RR, Akhter MP,  LRP5 Regulation of Intrinsic Material Properties of Cortical Bone. J Bone Miner. Res. 20: suppl 1:M050, 2005
  • Cullen DM, Akhter MP, Johnson ML, Morgan S, Recker RR. Ulna Loading Response Altered by the HBM Mutation. J Bone Miner. Res. 19: suppl 1:M217,, 2004
  • Akhter MP, Lund AD, Morgan S, Wells DJ, Cullen DM  Tobacco Smoking Effects on Bone Biomechanical Properties. J Bone Miner. Res. 19: suppl 1:SU507, 2004
  • Tanner SJ, Yee JA, Cullen DM. Mechanical loading initiates cell proliferation in vivo Podium Presentation Med Sci Sports and Exercise. 35: S4, 2003
  • Akhter MP, Wells DJ, Lydia P, Cullen DM. Bone Biomechanical Properties in Prostaglandin EP4 Knock-out Mice. Trans.49th Ann.Meeting Orthop.Res.Soc (ORS), New Orleans, LA. Poster # 416, 2003
  • Cullen DM, Carter J, Morgan S, Gentry-Nielsen M, Akhter MP. Cortical Bone Response to Long-term Smoke and Ethanol Exposure. J Bone Mineral Res 17: supp, 2003
  • M. P. Akhter, S. J. Short, D. J. Wells, D. M. Cullen. Bone Adaptation Response to Mechanical Loading In Mice Ulnae., J. Bone Miner. Res., 18, 2003
  • Cullen DM, Akhter MP, Mace D, Johnson ML, Babij P, Recker RR. Bone Sensitivity To Mechanical Loads with the Lrp5 HBM Mutation. J Bone Mineral Res  16:S332, 2002
  • J Barry, A Peyton, S Tanner, D Cullen, Bone cell response to mechanical loading and anabolic agents J Bone Mineral Res 16:S329, 2002
  • Akhter MP, Cullen DM, Wells DJ, Johnson ML, Babij P, Haynatzki GR, Recker RR Effects of a mutation in the Lrp5 gene on bone biomechanical properties J Bone Mineral Res 16:S432, Not Applicable, 2002
  • Akhter MP, Wells DJ, Cullen DM Indomethacin suppresses the bone adaptation response to mechanical loading in C57BL/6J mice J Bone Mineral Res 16:S432, Not Applicable, 2002
  • Cullen D, Tanner S, Gong G, Smith R, Akhter M. Prostaglandin and DNA synthesis in bone with mechanical loading. Trans.48th Ann.Meeting Orthop.Res.Soc, 2002
  • Cullen D. M., Peyton A. C., Gentry-Nielsen M. J., Akhter M. P. Bone Turnover with In vivo Smoke and Ethanol Exposure, Journal of Bone and Mineral Research, 16, S387, 2001
  • Akhter MP, Hull TW, Gentry-Nielsen M. J., Cullen DM, Recker RR Bone strength properties with tobacco smoke and ethanol exposure in rats, Journal of Bone and Mineral Research, 16, S387, 2001
  • Akhter MP, Hynatzki G, Cullen DM, Recker RR, Gairola GG Tobacco smoke exposure and bone biomechanical properties, Journal of Bone and Mineral Research, 16, S388, 2001
  • Tanner SJ, Yee JA, Cullen DM. Pre-osteoblast proliferation following in vivo mechanical loading., Journal of Bone and Mineral Research, 16, S203, 2001
  • Smith EL, Boudriot U, Daume B, Kratz M., Jones DB and Cullen DM,. Long term perfusion loading of trabecuar bone cores and formation rate, Journal of Bone and Mineral Research, 16, S481, 2001
  • Akhter, M.P., D.M. Cullen, and R.R. Recker. Alendronate treatment on bone biomechanical properties. Trans.46th Ann.Meeting Orthop.Res.Soc, Trans.46th Ann.Meeting Orthop.Res.Soc, 25, 762, 2001
  • Cullen DM, Peyton AC, Akhter MP, Gong G. Mechanical loading response in EP2 knockout mice., J. Bone Miner. Res., 15, S347, 2000
  • Akhter MP, Iwaniec UT, Otero JK, Covey MA, Cullen DM, Kimmel DB, Recker RR. Genetic variation in vertebral biomechanics and histomorphometry in three breeds of mice, J. Bone Miner. Res., 15, S485, 2000
  • Akhter MP, Iwaniec UT, Covey MA, Cullen DM, Recker RR. Nicotine and biomechanical properties in bone. J.Bone Miner.Res. 15: Suppl, 2000
  • Iwaniec U, Cullen DM, Kosta N, Tanner S, Akhter MP, Fung E. Effects of nicotine on cancellous bone in aged female rats, J. Bone Miner. Res., 15, S533, 2000
  • Gong G, Cullen DM, Peyton AC, Akhter MP, Recker RR. EP1 antagonist inhibition of bone formation induced by mechanical loading, J. Bone Miner. Res., 15, S477, 2000
  • Iwaniec U, Cullen DM, Kosta N, Akhter MP, Fung E. Effects of nicotine on cortical bone in aged female rats., J. Bone Miner. Res., 15, S413, 2000
  • Cullen DM, Peyton AC, Akhter MP, Gone G, Johnson ML. EP1 receptor knockout mice response to mechanical loading., J. Bone Miner. Res., 15, S476, 2000
  • Akhter, M.P., D.M. Cullen, and R.R. Recker. Alendronate treatment on bone biomechanical properties. Trans.46th Ann.Meeting Orthop.Res.Soc 762, 2000
  • Akhter, M.P., D.M. Cullen, and R.R. Recker. Biomechanical properties of bone in prostaglandin EP2knockout mice. Trans.46th Ann.Meeting Orthop.Res.Soc 743, 2000
  • Cullen, D.M., A.C. Peyton, and M.P. Akhter. Aged rat bone response to in vivo mechanical stimulation. J.Bone Miner.Res. 14: S413, 1999
  • Akhter, M.P., M.A. Covey, D.M. Cullen, G. Gong, and R.R. Recker. Bone mass and strength properties in EP1 knockout and wild type mice. J.Bone Miner.Res. 14: S550, 1999
  • Akhter, M.P., M.A. Covey, D.M. Cullen, and R.R. Recker. Tibial bone response to mechanical stimulus in two mice breeds., J Bone Miner Res, 14, S549, 1999
  • Iwaniec, U., Y.K. Fung, M. Akhter, M.C. Haven, M. Schmid, and D.M. Cullen. Effects of nicotine on bone and calcitropic hormones in growing female rats. J.Bone Miner.Res. 14: Suppl, 1999
  • Yee, J.A., L. Yan, D.M. Cullen, M.P. Akhter and R.R. Recker. Nicotine inhibits bone nodule formation by neonateal rat calvarial cells in vitro., J Bone Miner Res, 14, S239, 1999
  • Tanner SJ, Yee JA, Peyton AC, Cullen DM. Mechanical loading and periosteal cell proliferation in aged rats, J Bone Miner Res, 14, S413, 1999

Presentations

  • Huggett K, White MD, Knoop FC, Cullen D. Team based learning in anatomy: Promoting active learning and professionalism. IAMSA national meeting, San Diego, Ca 2015, 2015
  • Huggett K, White MD, Cullen D, Knoop FC. Lightning rounds: Promoting active learning and retrieval practice in anatomy labs. IAMSA national meeting, San Diego, Ca 2015, 2015
  • American College of Sports Medicine National Meeting Symposium Speaker: “From Dense Bones to a New Mechanotransduction Signaling Pathway” San Diego, Ca 2015., 2015
  • McCumber TL, Hackfort BT, Akhter MP, Cullen DM. In Vivo Fatigue Damage in Bone Linked to Cytokine Expression, 2014
  • Hackfort BT, Akhter MP, Cullen DM. Cyclooxygenase Response to Multiple Mechanical Loads in Mice. American Society of Bone and Mineral Research October 2014, 2014
  • Bone Turnover in High Bone Mass Mice, ORC Conference, 2004
  • Smoke and Alcohol Effects on Bone, ORC Conference, 2004
  • 18. DM Cullen, M Gentry-Nielson, MP Akhter “Interaction of Alcohol and Cigarette Smoke on Skeletal Health” at Great Plains States Society of Molecular Biology and Genetics Invited, 2003
  • Akhter MP, Wells DJ, Lydia P, Cullen DM (2002) Bone Biomechanical Properties in Prostaglandin EP4 Knock-out Mice. Abstract accepted for 49th Annual meeting of Orthopaedic Research Society (ORS), New Orleans, LA. Poster # 416, 2003, 2003
  • 21. Akhter MP, Wells DJ, Lydia P, Cullen DM (2002) Bone Biomechanical Properties in Prostaglandin EP4 Knock-out Mice. 49th Annual meeting of Orthopaedic Research Society (ORS), New Orleans, LA. Poster # 416, 2003, 2003
  • American Society of Bone and Mineral Research, Physical Activity Working Group “ Mechanical Loading and PTH stimulation of DNA Synthesis”. Fall 2002, 2002
  • 19. Cullen, DM. American Society of Bone and Mineral Research, Physical Activity Working Group, “The HBM mutation and mechanical regulation” National/International Presentation, 2002
  • Cullen D, Tanner S, Gong G, Smith R, Akhter M Prostaglandin and DNA synthesis in bone with mechanical loading. ORS 2002 meetingRes 16:S332, 2002., 2002
  • Akhter MP, Cullen DM, Wells DJ, Johnson ML, Babij P, Haynatzki GR, Recker RR Effects of a mutation in the Lrp5 gene on bone biomechanical properties J Bone Mineral Res 16:S432, 2002, 2002
  • Akhter MP, Wells DJ, Cullen DM Indomethacin suppresses the bone adaptation response to mechanical loading in C57BL/6J mice J Bone Mineral Res 16:S432, 2002., 2002
  • J Barry, A Peyton, S Tanner, D Cullen, Bone cell response to mechanical loading and anabolic agents J Bone Mineral Res 16:S329, 2002., 2002
  • Cullen D, Tanner S, Gong G, Smith R, Akhter M Prostaglandin and DNA synthesis in bone with mechanical loading, ORS National Meeting, 2002
  • Cullen D. M., Peyton A. C., Gentry-Nielsen M. J., Akhter M. P. Bone Turnover with In vivo Smoke and Ethanol Exposure, ASBMR National Meeting, 2001
  • Akhter MP, Hull TW, Gentry-Nielsen M. J., Cullen DM, Recker RR Bone strength properties with tobacco smoke and ethanol exposure in rats, ASBMR National Meeting, 2001
  • Akhter MP, Hynatzki G, Cullen DM, Recker RR, Gairola GG Tobacco smoke exposure and bone biomechanical properties, ASBMR National Meeting, 2001
  • Smith EL, Boudriot U, Daume B, Kratz M., Jones DB and Cullen DM,. Long term perfusion loading of trabecuar bone cores and formation rate, ASBMR National Meeting, 2001
  • Tanner SJ, Yee JA, Cullen DM. Pre-osteoblast proliferation following in vivo mechanical loading. , ASBMR National Meeting, 2001
  • “Bone cell response to mechanical loading and anabolic pharmaceutical agents” to be presented at Midwest Student Medical Research Forum 2001, 2001
  • Akhter, M.P., D.M. Cullen, and R.R. Recker. Alendronate treatment on bone biomechanical properties. Trans.46th Ann.Meeting Orthop.Res.Soc 762, 2000, 2001
  • Cullen DM, Peyton AC, Akhter MP, Gong G. Mechanical loading response in EP2 knockout mice. J.Bone Miner.Res. 15: S347, 2000., 2000
  • Cullen DM, Peyton AC, Akhter MP, Gone G, Johnson ML. EP1 receptor knockout mice response to mechanical loading. J.Bone Miner.Res. 15: S476, 2000, 2000
  • Akhter MP, Iwaniec UT, Covey MA, Cullen DM, Recker RR. Nicotine and biomechanical properties in bone. Iwaniec U, Cullen DM, Kosta N, Akhter MP, Fung E. Effects of nicotine on cortical bone in aged female rats. J.Bone Miner.Res. 15: S413, 2000, 2000
  • Iwaniec U, Cullen DM, Kosta N, Tanner S, Akhter MP, Fung E. Effects of nicotine on cancellous bone in aged female rats. J.Bone Miner.Res. 15: S533, 2000., 2000
  • Akhter MP, Iwaniec UT, Otero JK, Covey MA, Cullen DM, Kimmel DB, Recker RR. Genetic variation in vertebral biomechanics and histomorphometry in three breeds of mice. J.Bone Miner.Res. 15: xxx, 2000, 2000
  • Gong G, Cullen DM, Peyton AC, Akhter MP, Recker RR. EP1 antagonist inhibition of bone formation induced by mechanical loading. J.Bone Miner.Res. 15: S477, 2000., 2000
  • Iwaniec U, Cullen DM, Kosta N, Akhter MP, Fung E. Effects of nicotine on cortical bone in aged female rats. Iwaniec U, Cullen DM, Kosta N, Akhter MP, Fung E. Effects of nicotine on cortical bone in aged female rats. J.Bone Miner.Res. 15: S413, 2000, 2000
  • Thirtieth International Sun Valley Workshop on Hard Tissue Biology " Neuromuscular Function And The Implications For Bone ", 2000
  • Aged rat bone response to in vivo mechanical stimulation, NIH, 1999
  • Bone mass and strength properties in EP1 knockout and wild type mice, NIH, 1999
  • Alendronate treatment on bone biomechanical properties, NIH, 1999
  • Tibial bone response to mechanical stimulus in two mice breeds, HFF, 1999
  • Biomechanical properties of bone in prostaglandin EP2 knockout mice, NIH;, 1999
  • Effects of nicotine on bone and calcitropic hormones in growing female rats, Smokeless Tobacco, 1999
  • Mechanical loading and periosteal cell proliferation in aged rats, NIH, 1999
  • Nicotine inhibits osteoblast differentiation in cultures of neonateal rat calvarial cells, Nebraska Smoking, 1999

Research and Scholarship

Research and Scholarship Interests

  • Bone cell response to mechanical forces with an emphasis on increasing bone mass and preventing osteoporosis.