Mark J. Holmberg, MD, PhD
Mark J. Holmberg, MD, PhD

Mark J. Holmberg, MD, PhD

Professor
School of Medicine

Academic Appointments

Department

  • Medicine

Position

  • Professor

Education

  • Iowa State University,BS,1976-79
  • Creighton University School of Medicine,MD,1983-87

Certifications

American Board of Internal Medicine:       
            Internal Medicine:                                    
            Cardiovascular Diseases:                          
American Board of Echocardiography
Adult Comprehensive Echocardiography
 

Publications and Presentations

Articles


  • Vallabhajosyula S, Sundaragiri PR, Kanmanthareddy A, Ahmed AA. Mahfood Haddad T, Rayes HA, Khan AN, Buaisha HM, Pershwitz GE, McCann DA, Holmberg MJ, Morrow LE. Influence of left ventricular hypertrophy on in-hospital outcomes in acute exacerbation of chronic obstructive pulmonary disease. COPD. 2016;13(6):712-717. PMID: 27379826
     , COPD, 13;6, 712-17, 2016
  • Smer A, Alla V, Chandraprakasam S, Abuzaid A, Saurav A, Holmberg J. Saphenous venous graft pseudoaneurysm: a review of the literature. J Card Surg. 2015 Jan;30(1):70-3, Journal of Cardiovascular Surgery, 30;1, 70-3, 2015

  • Deshmukh A, Schima SM, White MD, Arouni AJ, Holmberg MJ. Right-Heart Failure and Hypotension after Arteriovenous Graft Placement in a Patient with Idiopathic Tricuspid Annular Dilatation. J Heart Valve Dis. 2012 MAY;21(3):406-7.
     , Journal of Heart Valve Disease, 21:3, 406-7, 2012
  • Shen X, Li H, Holmberg MJ, Cloutier D, Aryana A,Rovang K, Hee T, Mooss AN, Mohiuddin SM. Correlation between QRS Duration and Various Echocardiographic Parameters in Patinets scheduled to receive the Biventricular Pacemaker. Submitted to AHA 2005, American Heart Asso, 2005
  • Holmberg MJ, Shen X, Li H, Lakkireddy DJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Anticoagulation on Thromboembolism in Atrial Fibrillation Patients with and without left Atrial Thrombi Documented by Transesophageal Echocardiography. Submitted to AHA 2005, American Heart Asso, 2005
  • Shen X, Li H, Hee T, Lakkireddy DJ, Holmberg MJ, Cloutier D, Rovang K, Mooss AN, Mohiuddin SM. Does mitral regurgitation provide protection against the formation of left atrial thrombus and embolic cerebral vascular accident in patients with atrial fibrillation? Submitted to Chest 2005, Chest, 2005
  • Shen X, Li H, Lakkireddy DJ, Thambidorai S, Cloutier D, Holmberg MJ, Mooss AN, Mohiuddin SM. Does the aortic atherosclerotic plaques severity correlate with embolic events? Submitted to Chest 2005, Chest, 2005
  • Shen X , Holmberg MJ, Sype J, Hunter C, Mooss AN, Mohiuddin SM.Real-time three-dimensional echocardiography in diagnosis of right ventricular pseudoaneurysm after pacemaker implantation. Echocardiography 2005 in press, Echocardiography, 2005
  • Shen X, Li H, Holmberg MJ, Lakkireddy DJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Left atrial thrombus in patients with atrial fibrillation: the benefit of anticoagulation and the implication of clot persistence. Submitted to Clinical Coardiology 2005, Clinical Cardiology, 2005
  • Holmberg MJ, Shen X, Li H, Lakkireddy DJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Thromboembolism in atrial fibrillation patients with and without left atrial thrombi documented by transesophageal echocardiography. Submitted to Chest 2005, Chest, 2005
  • Shen X, Li H, Rovang KS, Hee TT, Holmberg MJ, Mooss AN, Mohiuddin SM. Transesophageal Echocardiography Before Cardioversion of Recurrent Atrial Fibrillation: Does Absence of Previous Atrial Thrombi Preclude the Need of a Repeat Test? Am Heart J 2003;146:741-755, American Journal of Cardiology, 146, 741-755, 2003
  • Lakkireddy DJ, Shen XD, Li H, Holmberg MJ, Cloutier D, Rovang K, Hee T, Mooss AN, Mohiuddin SM. Prognosis of Patients with Persistent Atrial Thrombus and Atrial Fibrillation on Anticoagulation. Circulation 2003, Circulation, 2003
  • Prevention of Intra-Atrial Thrombi in Atrial Fibrillation. Patients with subtherapeutic International Normalized Ratios while Taking Conventional Anticoagulation. Shen XD, Li H, Rovang K, Hee T, Holmberg MJ, Mooss AN, Mohiuddin SM., American Journal of Cardiology, 90 (6), 660-662, 2002
  • Holmberg MJ, Abdul-Aziz S, Shen XD, Price C, Li HG, Johnson TC, Mooss, AN, Mohiuddin SM. A novel approach to improve accuracy of measurement of left ventricular function in patienbts with suboptimal echocardiogram images., Journal of Heart Failure, 7(1), 2002
  • Shen X, Holmberg MJ, Johnson T, Mooss AN, Mohiuddin S: Measurement of left ventricular volume by echocardiographic automated border detection in models with contrast micro-bubbles, J Heart Disease, 2001
  • Benzocaine-Induced Methemoglobinemia during an outpatient procedure., Pharmacotherapy, 20, 735-738, 2000
  • Correlation of Intensity of AS Murmur..., Not Applicable, 1999

Publications


  • Gangi RP, Akinapelli A, Koneru S, Matta A, Vallabhajosyula S, Bellamkonda P, Alla V, Mooss A, Nair C, Holmberg M, Sugimoto J. IMPACT OF MITRAL ANNULAR CALCIFICATION ON OUTCOMES OF AORTIC VALVE SURGERY. J Am Coll Cardiol. 2014 4/1;63(12, Supplement):A2010.
     , JACC, 63:12, A2010, 2014
  • Lavu M, Holmberg M. ADDISON'S DISEASE PRESENTING AS ‘STEMI’. J Am Coll Cardiol. 2014 4/1;63(12, Supplement):A657, JACC, 63;12, A657, 2014
  • Kaushik M, Saurav A, Smer A, Alla VM, Khan S, Madan R, Holmberg MJ, Mohiuddin, S.  Epicardial Adipose Tissue as Assessed by Echocardiography and Incident Cardiac Disease. J Am Coll Cardiol. 2012 MAR 27;59(13):E1159, JACC, 59;13, E1159, 2012
  • Shen X, Li H, Nair CK, Holmberg MJ, Lakkireddy D, Cloutier D, Rovang K, Hee TT, Mooss AN, Mohiuddin SM. Different implications of left atrial thrombus detected by transesophageal echocardiography in atrial fibrillation patients with and without warfarin therapy. ACC (Accepted) 2006., ACC Current Journal Review, 2006
  • 21. Xuedon Shen, M.D., Holmberg, MJ, John Sype, M.D., Claire Hunter, M.D., Aryan N. Mooss, M.D., and Syed M. Mohiuddin, M.D.;”Real-Time Three-Dimensional Echocardiography in Diagnosis of Right Ventricular Pseudoaneurysm after Pacemaker Implantation”; Echocardiography A Journal of Cardiovascular Ultrasound and Allied Techniques, Volume 23, Number 3, pp 240-243, March 2006, Journal of Cardiovascular Ultrasound & Allied Techniques, 23 #3, 240-243, 2006
  • 19. Shen XD, Li HU, Holmberg MJ, Reddy M, Kusler M, Almeida N, Cloutier D, Rovang K, Hee T, Mooss A, Mohiuddin SM. Outcome in Heart Failure in Narrow QRS Patients With and Without Left Ventricular Dyssynchrony. J Am Coll Cardiol 2006; 47(4): 99A., J American College of Cardiology, 47 (4), 99A, 2006
  • Shen XD, Li HU, Nair C, Holmberg MJ, Cloutier D, Rovang K, Hee T, Mooss A, Mohiuddin SM. Warfarin Therapy Initiated Before Transesophageal Echocardiography Detected Left Atrial Thrombus is More Beneficial than When Started After. J Am Coll Cardiol 2006; 47(4): 152A., J American College of Cardiology, 47 (4), 152A, 2006
  • Shen XD, Li HU, Lakkireddy DJ, Holmberg MJ, Cloutier D, Rovang K, Hee T., Moss A, Mohiuddin SM. The Impact of Anticoagulation on Cerebrovascular Accidents in Patients with Atrial Fibrillation and Left Atrial Thrombi Documented by Transesophageal Echocardiography. J. Am Soc Echocardiog 2005;18 (5):561, Journal of American Echo Society, 18, 561, 2005
  • Thambidorai S, Shen X, Nair CK, Li H, Lakkireddy DJ, Cloutier D, Holmberg MJ, Mooss AN, Mohiuddin SM. The incidenceof Embolic Stroke in Patients with Left Atrial Thrombus and/or Thoracic Aortic Plaques Assessed by Transesophageal Ehocardiography. J Am Soc Echocardiogr 2005;18(5):565, Journal of American Echo Society, 18, 565, 2005
  • Repeat Transesophageal Echocardiography before Cardioversion of Recurrent atrial fibrillation. Is it Necessary in Undercoagulated Patients who had no Previous Atrial Thrombi? Shen XD, Li HG, Rovang KS, Hee T, Holmberg MJ, Mooss AN, Mohiuddin SM., Circulation, 2002
  • Automatead Echocardiographic Determination of Left Ventricular Function in Patients with Suboptimal Endocardial Visualization. Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, Del Core M, Mooss AN, Mohiuddin SM, Porter TR., Circulation, 2002
  • Contrast Echocardiography Enhances Automated Border Detection Evaluation of Left Ventricular Function as compared to Manual Tracing. Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, Del Core M, Mooss AN, Mohiuddin SM, Circulation, 2002
  • Shen X, Li H, Rovang K, Hee T, Holmberg JM, Mohiuddin SM. Transesophageal echocardiography before cardioversion of atrial fibrillation: Is it needed for patients receiving conventional antocoagulation but having sibtherapeutic INR?, J American College of Cardiology, 39, 376 A, 2002
  • Peripheral Endothelial Function: Is There a Gender Difference? in Oct '99 Chest, Not Applicable, 1999
  • Does Ausculatory Grade of AS Murmur... in Journal of American Society of Echocardiography Jul '99, Not Applicable, 1999

  • Smer A, Alla V, Chandraprakasam S, Abuzaid A,Saurav A, Holmberg J. Saphenous venous graft pseudoaneurysm: A review of the literature. J Card Surg 2015; 30(1):70-73.
     

Editing and Reviews


  • Holmberg, MJ (contributing editor) Koster  N.. Cardiovascular Imaging Review, Expert Consult-Online and Print. Philadelphia, PA: Elsevier July 2011
     

General


  • Chandraprakasam S, Saurav A, Patel N, Sirineni G, Holmberg M, Nair C, Biddle W, Hunter C. RUPTURED SINUS OF VALSALVA ANEURYSM WITH SPONTANEOUS CLOSURE OF PERIMEMBRANOUS VENTRICULAR SEPTAL DEFECT: DIFFICULT DIAGNOSIS AND DISCREPANCIES IN MULTI-MODALITY IMAGING. J Am Coll Cardiol. 2014 4/1;63(12, Supplement):A614.
     , JACC, 2014 4/1;63(12, Supplement):A614., 2014

  • Vallabhajosyula S, Sundaragiri PR, Kanmanthareddy A, Ahmed AA. Mahfood Haddad T, Rayes HA, Khan AN, Buaisha HM, Pershwitz GE, McCann DA, Holmberg MJ, Morrow LE. Influence of left ventricular hypertrophy on in-hospital outcomes in acute exacerbation of chronic obstructive pulmonary disease. COPD. 2016;13(6):712-717. PMID: 273798
     , Criminology and Criminal Justice: Theory, Research Methods and Statistics

  • Vallabhajosyula S,Sundaragiri PR, Bellamkonda P, Holmberg MJ. Coronary arteriovenous fistula with coexisting atrial septal defect. BMJ Case Rep. 2014 May 5;2014.
     
  • Deshmukh A, Schima SM, White MD, Arouni AJ, Holmberg MJ. Right-heart Failure and Hypotension after Arteriovenous Graft Placement in a Patient with Idiopathic Tricuspid Annular Dilatation. J Heart Valve Dis. 2012; 21(3):406-407

  • Kaushik M, Saurav A, Smer A, Alla, VM, Khan S, Madan R, Holmberg MJ, Mohiuddin S. Epicardial adipose tissue as assessed by echocardiography and incident cardiac disease. J Am Coll Cardiol. 2012; 59(13):E1159-E1159.
     
  • Shen X, Nair, CK, Aronow W, Holmberg MJ, Reddy M, Anand K, Hee T, Chen A, Fang X, Maciejewski S, Esterbrooks D.  A New Baseline Scoring System May Help to Predict Response to Cardiac Resynchronization Therapy.  Arch Med Sci. 2011; 7(4):  627-633

  • Haddad M, Abuzaid A,Narayanan M, Holmberg M. Recurrent Spontaneous Coronary Artery Dissection Treated Medically. Circ 2014;I30:A20381
     

Presentations

  • “A Bridge Too Far?” presented at the Department of Medicine Grand Rounds, 2015
  • A True View of the Heart: 3-D Echocardiography, Creighton University Medical Center 07/07/2005., 2005
  • Tricuspid Regurgitation, Cardiology Grand Rounds, Creighton University Medical Center, 2005
  • 16. Contrast Echocardiography Enhance Automated Border Detection Evaluation of Left Ventricular Function as Compared to Manual Tracing. AHA, Chicago, IL., 2003
  • Holmberg MJ, AbdulAziz S, Shen XD, PRice C, Li HG, Johnson TC, DelCore M, Mooss AN, Mohiuddin SM, Porter TR. Automated Echocardiographic Determination of Left Ventricular Function in Patients with Suboptimal Endicardial Visualization. Presented at American Heart Association Scientific Session 2002, Chicago IL, 2002
  • Shen XD, Li HG, Rovang KS, Hee T, Holmberg MJ, Mooss AN, Mohiuddin SM. Repeat Transesophageal Echocardiography before Cardioversion of Recurrent atrial fibrillation. Is it Necessary in Undercoagulated Patients who had no Previous Atrial Thrombi? Presented at American Heart Association Scientific Session 2002, 2002
  • Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, DelCore M, Mooss AN, Mohiuddin SM. Contrast Echocardiography Enhances Automated Border Detection Evaluation of Left ventricular Function as compared to Manual Tracing. Presented at American Heart Association Scientific Session 2002, Chicago IL, 2002
  • Holmberg MJ. Stress echocardiography. Presented at American Association of Cardiovascular and Pulmonary Rehabilitation, 17th Annual Meeting, Charlotte, NC, 2002
  • Holmberg MJ, AbdulAziz S, Shen XD, Price C, Li HG, Johnson TC, Mooss AN, Mohiuddin SM. A novel approach to Improve Accuracy of Measurement of Left Ventricular Function in Patients with Suboptimal Echocardiogram Images. Presented at the 8th World Congress on Heart Failure-Mechanisms and Management, Washington DC, 2002
  • Management of Heart Failure. American Association of Cardiovascular and Pulmonary Rehabilitation Annual Meeting. Tampa, FL, 2000
  • Peripheral Endothelial Function: Is There a Gender Difference? Am. College of Chest Physicians, Chicago, IL Nov '99, 1999