David Zhi-Zhou He, MD, PhD
David Zhi-Zhou He, MD, PhD

David Zhi-Zhou He, MD, PhD

Professor
School of Medicine

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Professor

Education

  • Nanjing Railway Medical College,M.D.,1978 - 1983
  • Shanghai Institute of Physiology,Ph.D.,1985-1990

Publications and Presentations

Books

  • Beisel KW, He DZZ, Hallworth R & Fritzsch B (2008). Genetics of mechanoreceptor evolution and development. In: Audition, Vol. 1. (R. Hoy, P. Dallos, eds.), Elsevier, NY, pp 75-105, Not Applicable, I, 2008
  • Currall B, Wang X, He DZZ. The effect of streptomycin and gentamicin on outer hair cell motility, Biomechanics at Micro- and Nanoscale Levels, Vol. III, III, 5-12, 2007

Articles

  • Zhang Q, Liu HZ, Soukup GA, He DZ. Identifying miRNAs involved in aging of the stria vascularis., PLoS One, 9(11), 2014
  • Ren AJ, Wang K, Zhang H, Liu A, Ma X, Liang Q, Cao D, Wood JN, He DZ, Ding YQ, Yuan WJ, Xie Z, Zhang WJ. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons., Nature Communications, 5, 4984, 2014
  • Liu HZ, Pecka J, Zhang Q, Soukup GA, Beisel KW, He DZ. Characterization of transcriptomes of cochlear inner and outer hair cells., Journal of Neuroscience, 34, 11080, 2014
  • Li Yi, Liu H, Li J, Zhang Q, Gong S, He DZ (2014) Morphology and ciliary motion of mucosa in the Eustachian tube of neonatal and adult gerbils, PLoS One, 9(6), e99840, 2014
  • 53. He* DZ, Lovas S, Ai Yu, Yi Li, Beisel KW (2013). Prestin at year 14: Progress and prospect. Hear Res pii: S0378-5955(13)00288-8. doi: 10.1016/j.heares.2013.12.002., Hearing Research, 731, 3-11, 2013
  • Wang X, Yang SM, Jia SP, He* DZZ (2010). Prestin forms oligomer with four mechanically independent subunits., Brain Res, 1333, 28-35, 2010
  • He DZZ, Jia SP, Zuo J, Latham S, Riordan GP & Kachar B (2010). Prestin function and the structure of the lateral membrane of outer hair cells., cytoskeleton, 67, 43-55, 2010
  • Jia SP, Yang SM, Guo WW & He* DZZ (2009). Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia., Not Applicable, 29, 2009
  • Kumano S, Tan X, He DZZ, Iida K, Murakoshi M & Wada H (2009). Mutation-induced reinforcement of prestin-expressing cells., Biochem. Biophys. Res. Commun., 389, 569-574, 2009
  • Yang SM, Hou ZH, Young WY, Zhang JS, Yang G, Guo W, Sun JH, Hu YY, Yu N, Yu YP, He DZZ, Han DY & Yang X (2009). Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice., Developmental Dynamics, 238, 1897-1908, 2009
  • Dallos P, Wu X, Cheatham MA, Gao J, Zheng J, Anderson CT, Jia S, Wang X, Cheng WH, Sengupta S, He DZ, Zuo J. Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification., Neuron, 58, 333, 2009
  • Yang SM, Guo WW, Hu YY, Sun YX, Hou ZH, Sun JH, Wang X, He DZ, Zhai SQ, Young WY, Han DY, Yang X. Smad5 haplo insufficiency leads to hair cell and hearing loss, Developmental Neurobiology, 69, 153, 2009
  • Wu XD, Wang X, Gao JG, Yu YL, Jia SP, Zheng J, Dallos P, He DZZ, Cheatham MA, Zuo J. Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification., Brain Res, 1210, 20, 2008
  • Dallos P, Wu XD, Gao J, Wang X, Jia SP, Anderson CT, Zheng J, Cheatham MA, He* DZZ & Zuo* J. Prestin-based outer hair cell motility is necessary for Mammalian cochlear amplification., Neuron, 58, 333, 2008
  • Wang X, Jia SP, Currall B, Yang SM & He DZZ. Streptomycin and gentamicin have no immediate effect on outer hair cell electromotility., Hearing Research, 234, 52, 2007
  • Gao JG, Wang X, Wu XD, Aguinaga S, Huynh K, Jia SP, Matsuda K, Patel M, Zheng J, Cheatham MA, He* DZZ, Dallos* P & Zuo* J. Hyperpolarizing shifts of outer hair cell nonlinear capacitance and electromotility in prestin knockin mice do not change sensitivity or tuning., Proceedings of the National Academy of Sciences, 104, 12542, 2007
  • Albert JT, Winter H, Schaechinger TJ, Weber T, Wang X, He DZZ, Geisler H-S, Hendrich O, Zimmermann U, Gofert MC, Oliver D & Knipper M. Voltage-sensitive prestin orthologue expressed in zebrafish hair cells, Journal of Physiology, 580, 451-461, 2007
  • Jia SP, Dallos P & He DZZ. Mechanoelectric transduction of adult inner hair cells, Journal of Neuroscience, 27, 1006-1014, 2007
  • Jia SP, Zuo J, Dallos P & He DZZ. The cochlear amplifier: Is it hair bundle motion of outer hair cells? In: Auditory Mechanisms: Processes and Models. Nuttall A, Ren TY, Gillespie P, Grosh K, de Boer E (eds). Singapore, World Scientific Publ, Not Applicable, 261-269, 2006
  • He DZZ, Zheng J, Kalinec F, Kakehata S, Santos-Sacchi J. Tuning in to the amazing outer hair cell: membrane wizardry with a twist and shout, Journal of Membrane Biology, 209, 119-134, 2006
  • Jia SP, & He DZZ. Motility-associated hair-bundle motion in mammalian outer hair cells, Nature Neuroscience, 8, 1028-1034, 2005
  • He DZZ, Jia SP, & Dallos P. Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea, Nature, 429, 766-770, 2004
  • He DZZ, Cheatham MA, Pearce M, Vetter DE. Mouse outer hair cells lacking the alpha9 receptor are motile, Developmental Brain Research, 148, 19-25, 2004
  • He DZZ, Jia SP, & Dallos P. Prestin and the dynamtic stiffness of cochlear outer hair cells, Journal of Neuroscience, 23, 9089-9096, 2003
  • He DZZ, Beisel KW, Chen L, Ding DL, Fritzsch B, & Salvi R. Chick hair cells do not exhibit voltage-dependent somatic motility, Journal of Physiology, 546, 511-520, 2003
  • He DZZ, Jia SP, & Feng F. Thyroid hormone is not necessary for the development of outer hair cell electromotility, Hearing Research, 175, 183-189, 2003
  • He DZZ. Mechanical responses of cochlear outer hair cells. Biophysics of the Cochlea. From Molecules to Models. Gummer, A.W. (ed.), World Scientific, Not Applicable, 181-184, 2003
  • Liberman MC, Gao J, He DZZ, Wu XD, Jia SP,& Zuo J. Prestin is required for outer hair cell motility and the cochlear amplifier, Nature, 419, 300-304, 2002
  • Zheng J, He DZZ, Long K, Madison LD, & Dallos P. Identification of differentially expressed cDNA clones from cochlear outer hair cells using PCR-based suppression subtractive hybridization, Audiol. Neurootol., 7, 277-288, 2002
  • Gao JG, Wang X, Wu XD, Aguinaga S, Huynh K, Jia SP, Matsuda K, Patel M, Zheng J, Cheatham MA, He DZZ, Dallos P & Zuo J (2006). Prestin-based outer hair cell electromotility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier. Proc Natl Acad Sci USA (in press)
  • Wang X, Jia SP, Currall B, Yang SM & He DZZ (2007) Streptomycin and gentamicin have no immediate effect on outer hair cell electromotility. Hearing Res (under revision).
  • Beisel KW, He DZZ, Hallworth R & Fritzsch B (2007) Genetics of mechanoreceptor evolution and development. In: Audition, Vol. 1. (R. Hoy, P. Dallos, eds.), Elsevier, NY, (in press).
  • Currall B, Wang X, He DZZ (2007). The effect of streptomycin of streptomycin and gentamicin on outer hair cell motility. In: Biomechanics at Micro- and Nanoscale Levels, Vol. III, (H. Wada, ed). World Scientific Publ. (in press)

Publications

  • Regeneration of Stereocilia of Cochlear Hair Cells by Math1 Gene Therapy Shi-Ming Yang, Wei Chen, Wei-Wei Guo, Jian-He Sun, Ying-Yan Hu, Shuping Jia, David He, 28th Midwinter Meeting of the Association for Research in Otolaryngology, 33, 484, 2010
  • The Size of R Group Rather Than the Charge Alone Plays a Role in Voltage Sensing of Prestin Xiaodong Tan, Jason Pecka, Kirk Beisel, David He, 28th Midwinter Meeting of the Association for Research in Otolaryngology, 33, 577, 2010
  • Smad4 Gene Plays Important Role on Inner Ear Development in Mice Shi-Ming Yang, Zhao-Hui Hou, Guan Yang, Ji-Shuai Zhang, Wei-Wei Guo, Jian-He Sun, Wie-Yen Young, David He, Xiao Yang, 28th Midwinter Meeting of the Association for Research in Otolaryngology, 33, 32, 2010

Presentations

  • Seminar given at Biology Department of University of Iowa, 2015
  • Poster presentation at 48th ARO meeting in Baltimore, 2015
  • Podium presentation at 48th ARO meeting in Baltimore, 2015
  • Poster presentation at Inner Ear Biology Meeting in Japan, 2014
  • Podium presentation at Inner Ear Biology Meeting in Japan, 2014
  • Poster Presentation at annual ARO meeting, 2014
  • Poster presentation at annual Meeting, 2014
  • Seminar speaker at Boys Town National Research Hospital, 2010
  • Seminar Speaker at Qinghua University, 2010
  • Poster Presentation, ARO meeting, 2010
  • Oral Presentation ARO Meeting, 2010
  • Poster Presentation at ARO meeting, 2010
  • Seminar Speaker at Tohoko University, 2010
  • Invited Seminar Speaker, Medical University of South Carolina, 2010
  • 46th Inner Ear Biology Meeting, 2009
  • Seminar speaker at Johns Hopkins University, 2009
  • departmental seminar, 2009
  • ARO poster, 2009
  • ARO annual meeting, 2009
  • ARO poster presentation, 2009
  • Seminar speaker at University of Michigan, 2008
  • invited seminar at boys town national research hospital, 2008
  • 5th International Conference on Nanotechnology in Biomedical Research, 2008
  • invited seminar at NIDCD, NIH, 2008
  • Poster, Annual meeting of the Association for research of otolaryngology, 2008
  • Poster, Annual Meeting of the Association for research of otolaryngology, 2008
  • Podium presentation at Annual meeting of the Association for Research in Otolaryngology, 2008
  • Department Seminar, 2008
  • Keynote speaker, 30th international conference on comparative physiology, Brazil, 2007
  • Invited Seminar Speaker at UC Irvine, 2007
  • Feature Presentation at 4th International Conference on Hearing Sciences, Beijing, China, 2007
  • Invited Seminar at NIDCD/NIH, Bethesda, 2007
  • Poster Presentation at ARO Annual Meeting, Denver, 2007
  • Podium Presentation at ARO Annual Meeting, Denver, 2007
  • Seminar speaker at University of North Dakota, 2006
  • Seminar speaker at University of Washington, 2006
  • Prsentation at ARO, Baltimore, 2006
  • ARO Annual Meeting at Baltimore, 2006
  • Seminar speaker at Depts of Otolaryngology, and Physiology and Biophysics, University of Colorado, 2005
  • 2nd Swiss-Japan conference on biomechanics, Kyoto, Japan, 2005
  • Invited lecture at Koyto University, Japan, 2005
  • Auditory Mechanisms: Processes and Models. Oregon, Portland, USA, 2005
  • Invited seminar speaker at NIDCD (NIH), 2005
  • XXXI International conference of Physiology, 2005
  • Poster presentation at aro annual meeting, 2005
  • Assoc. Res. Otolaryngology mid winter meeting., 2005
  • Gordon research conference on neurobiology of the sensory system in Hong Kong, 2004
  • Gordon Research Conference in Hong Kong, 2004
  • ARO Annual Meeting in Florida., 2004
  • ARO Meeting in Florida, 2004
  • ARO Meeting in florida, 2004
  • The 2nd International Symposium on Future Medical Engineering Based on Bio-Nanotechnology, Japan., 2003
  • ARO Meeting, 2003
  • ARO Meeting, 2003
  • ARO Meeting, 2003
  • ARO Meeting, 2003
  • ARO Meeting, 2003
  • Presentations at the Annual Meeting of the Association for Research on Otolaryngology in Florida, 2003
  • ARO mid-winter meeting in Florida, 2003
  • Seminar speaker at UNMC, 2002
  • Presentation at the Meeting of Biophysics of the Cochlea in Germany, 2002

Awards and Honors

  • Intramural Research Award, 2006