Jason C. Bartz, PhD
Jason C. Bartz, PhD

Jason C. Bartz, PhD

Professor
Associate Dean, Academic and Faculty Affairs
Vice Chair, Medical Microbiology and Immunology
School of Medicine

Expertise/Specializations

  • Prion disease

Academic Appointments

Department

  • Med. Microbiology & Immunology

Position

  • Professor

Biography

Examples of the most recent publications can be obtained from this PubMed link
 

Education

  • University of Wisconsin-Stevens Point,BS - Biology,1986-1990
  • University of Wisconsin-Madison,MS-Veterinary Science,1992-1994
  • University of Wisconson-Madison,Ph.D.,1994-19981002

Publications and Presentations

Articles

  • Prion Strain Diversity. Jason C. Bartz In "Prion Diseases" Ed. Stanly B. Prusiner, Cold Spring Harbor Press, 2017
  • PrPSc formation and clearance as determinants of prion tropism. Ronald A. Shikiya1, Katie A. Langenfeld1, Thomas Eckland1, Jonathan Trinh1, Alan M. Elder2, Candace K. Mathiason2, Anthony E. Kincaid1,3 and Jason C. Bartz1*, Proceedings of the National Academy of Sciences, 2016
  • Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice. Kincaid, AE, Ayers, JI and Jason C. Bartz, Journal of Virology, 90 (18), 8293-8301, 2016
  • Non-adaptive prion amplification during interspecies transmissions. Jifeng Bian1, Vadim Khaychuk1†, Kristi Bowling2, ‡, Rachel Angers2, Natalia Fernández-Borges3, Enric Vidal4, Crystal Reid Myerett1, Sehun Kim1, Carla Calvi1, Jason Bartz5, Ed Hoover1, Umberto Agrimi6, Jürgen A. Richt7¶, Joaquín Castilla3,8, and Glenn Telling1,*, Proceedings of the National Academy of Sciences, 2016
  • From slow viruses to Prions. Jason C. Bartz, PLoS Pathogens, 12 (7), e1005543, 2016
  • Incongruity between Prion Conversion and Incubation Period following Confection. Langenfeld KA, Shikiya RA, Kincaid AE and Jason C. Bartz, Journal of Virology, 90 (12), 5715-5723, 2016
  • Investigation of Bovine Serum Albumin (BSA) Attachment onto Self-Assembled Monolayers (SAMs) Using Combinatorial Quartz Crystal Microbalance with Dissipation (QCM-D) and Spectroscopic Ellipsometry (SE), Hanh T. M. Phan, Shannon Bartelt-Hunt , Keith B. Rodenhausen, Mathias Schubert and Jason C. Bartz, PLoS One, 10.1371, 0141282, 2015
  • Investigation of Bovine Serum Albumin Attachment Onto Self-Assembled Monolayers Using Combinatorial Quartz Crystal Microbalance With Dissipation and Spectroscopic Ellipsometry. Hanh T.M. Phan, Shannon Bartelt-Hunt, Keith B. Rodenhausen, Mathias Schubert and Jason C. Bartz., PLoS One, 10 (10), e0117935, 2015
  • Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations. Elder AM, Henderson DM, Nalls AV, Hoover EA, Kincaid AE, Bartz, JC and Candace K. Mathiason, Journal of Virology, 89 (14), 7421-7424, 2015
  • Immediate and ongoing detection of prions in the blood of hamsters and deer following oral, nasal, or blood inoculations. Elder AM, Henderson DM, Nalls AV, Hoover EA, Kincaid AE, Bartz JC, Mathiason CK., Journal of Virology, Jul;89(14), 7421-4, 2015
  • Prion Diseases. E. Belay and J. Bartz, In ”Viral Infections of Humans” Eds, R. Kaslow, L. Stanberry and J. LeDuc., Springer Publishing, 5th Edition, 1165-1186, 2015
  • Nasal associated lymphoid tissue of the Syrian golden hamster expresses high levels of PrPC. Clouse MD, Shikiya RA, Bartz JC, Kincaid AE., PLoS One, 10(2), 2015
  • Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting. Yuan Q, Eckland T, Telling G, Bartz J, Bartelt-Hunt S., PLoS Pathogens, 11(2), 2015
  • Prion formation, but not clearance, is supported by protein misfolding cyclic amplification. Shikiya RA, Eckland TE, Young AJ, Bartz JC., Prion, 8(6), 415-420, 2014
  • In vitro detection of prionemia in TSE-infected cervids and hamsters. Elder AM1, Henderson DM, Nalls AV, Wilham JM, Caughey BW, Hoover EA, Kincaid AE, Bartz JC, Mathiason CK., PLoS One, Nov 1;8(11):e80203. doi: 10.1371/journal.pone.0080203, 2013
  • Prion strain interference. Schutt, C.R., Shikiya, R.A., and Bartz, J.C., Springer Publishing, 2013
  • The influence of soil attachment on the biologic properties of the prion protein. S.L. Bartelt-Hunt, Sauders, S.E. and Bartz, J.C., Not Applicable, 2013
  • Prions in the Environment. Bartelt-Hunt, S.L., and Bartz, J.C. and Saunders, S.E., Not Applicable, 2013
  • Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus). Marsh, R.F., Kincaid, A.E., Bessen, R.A. and Bartz, J.C., Journal of Virology, 79, 13794-13796, 2005
  • Safety and Toxicological Evaluation of a Novel Niacin-Bound Chromium (III) Complex. Shara, M., Yasmin, T., Kincaid, A.E., Limpach, A.L., Bartz, J.C., Brenneman, K.A., Chatterjee, A., Bagchi, M., Stohs, S.J. and Bagchi, D., Journal of inorganic biochemistry, 99 (11), 2161-2183, 2005
  • Extraneural prion neuroinvasion without lymphoreticular system infection. Bartz, J.C., , Crista DeJoia, C., Tucker, T., Kincaid, A.E., and Bessen,, R.A., Journal of Virology, 79, 11858-11863, 2005
  • Detection of PrPSc in skeletal muscle and papillae of the tongue., Journal of Virology, 78, 6792-6798, 2005
  • Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy by prior peripheral inoculation with the replication deficient DY strain. Bartz, J.C., Aiken, J.M. and Bessen, R.A., Journal of General Virology, 85, 265-273, 2004
  • Rapid prion neuroinvasion following tongue infection, Journal of Virology, 77, 583-591, 2004

Publications

  • Restricted propagation of sheep scrapie in hamsters. Shikiya RA, Soto PA, Young, A and Jason C. Bartz, Prion, 2016
  • Prion strain interference is a common property of prions. Katie Langenfeld and Jason Bartz, Prion, 2015
  • Conformational dynamics of the cellular prion protein. Patricia Soto1, Natalie Bui2, Margaret Carter3, Roger Gonzales3, William Graft4, Angela Lax3, Chad Nieri3, Bo Zhao1, and Jason Bartz5, Prion, 2015
  • The prion protein in chemosensitive cells of the carotid body in uninfected and infected hamsters Anthony Kincaid, Melissa Clouse, Albert Lorenzo, and Jason Bartz, Prion, 2015
  • Non-adaptive prion amplification (NAPA): Interspecies prion propagation liberated from the constraints of species- specific PrP primary structure Jifeng Bian1, Vadim Khaychuk1, Jason Bartz2, Joaquin Castila3, Sehun Kim1, and Glenn Telling1, Prion, 2015
  • Prion soil binding may explain efficient horizontal CWD transmission Nathaniel Denkers1, Davin Henderson1, Shannon Bartelt-Hunt2, Jason Bartz3, and Edward Hoover1, Prion, 2015
  • Detecting the temporal status of prionemia in transmissible spongiform encephalopathy-infected hosts Alan Elder1, Davin Henderson1, Amy Nalls1, Kristen Davenport1, Anthony Kincaid2, Edward Hoover1, Jason Bartz2, and Candace Mathiason1, Not Applicable, 2015
  • Mitigation of prion infectivity and conversion capacity by a simulated natural process—repeated cycles of drying and wetting Qi Yuan2,*, Thomas Eckland2, Glenn Telling3, Jason Bartz2, and Shannon Bartelt-Hunt1, Prion, 2015

Presentations

  • "The environmental fate of prions" Rocky Mountain Virology Meeting, Ft. Collins Colorado, 2015
  • Prion strain tropism - NeuroPrion 2015, 2015
  • University of Nebraska Medical Center - Prion disease lecture for Pharmacology 930, 2015
  • University of Nebraska - Lincoln. Prion disease lecture for Viral Pathogenesis graduate student class, 2014
  • University of Nebraska: The biology of prion diseases, 2014
  • Iowa State University: Prion strain interference, 2014
  • University of Nebraska: Prion strain interference, 2014
  • “Prion strain selection in the central nervous system” University of Minnesota, Minneapolis., 2005
  • “Prion strain selection” United States Department of Agriculture, Animal Research Service. Ames, IA., 2005
  • “Prion strain selection and targeting in the central nervous system” Nebraska center for virology external advisory meeting. Lincoln, NE., 2005
  • “Prion diseases of humans and animals” Nebraska Infection Control Network 25th anniversary educational conference. Omaha NE. August 11-12, 2005., 2005
  • Sigurdson, C., Aguzzi, A., Hoover, E., MAthiason, C., Perrott, M., Glatzel, M., Bartz, J.C., Manco, G., Sprker, T. and Miller, M. (2005). Chronic wasting disease: across the species barrier. The Second International Chronic Wasting Disease Symposium. Madison WI. July 12-14, 2005., 2005
  • Ayers, J.A., Kincaid, A.E. and Bartz, J.C. (2005). Prion strain targeting. The Second International Chronic Wasting Disease Symposium. Madison WI. July 12-14, 2005., 2005
  • “Prion strain selection in the central nervous system” The Second International Chronic Wasting Disease Symposium. Madison WI. July 12-14, 2005., 2005
  • “Prion pathogenesis” AOAC International meeting and exposition. Kansas City, Missouri., 2005
  • “Prion diseases of humans and animals” Nebraska and Iowa Clinical Science Laboratory Meeting. Mid-America Center, Council Bluffs, IA., 2005
  • “Prion strain targeting and competition in the central nervous system” Department of Veterinary Science, South Dakota State University, Brookings SD., 2005
  • “Interspecies transmission of prion diseases” Creighton University Medicine, 2005
  • “Interspecies transmission of prion diseases” Okalahoma State University, Stillwater OK., 2005
  • “Interspecies transmission of prion diseases” University of Nebraska Medical Center Department of Genetics, Cell Biology and Anatomy Seminar Series, Omaha, NE., 2005
  • “Prion diseases of humans and animals” University of Nebraska Medical Center Molecular Diagnostics Laboratory Group, Omaha, NE., 2005
  • Kincaid, A.E, Kramer, M. and Bartz, J.C. (2005). Prion strain competition in the central nervous system. Keystone Symposia “Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases)”. Snowbird, UT., 2005
  • “Interspecies transmission of prions” Nebraska Infectious Disease Seminar., 2004
  • “Prion competition in the central nervous system” Animal prion diseases and the Americas, Ames IA., 2004
  • “Prion strain targeting and competition” Fourth annual Nebraska Center for Virology Symposium in Virology. University of Nebraska – Lincoln., 2004
  • “Interspecies transmission of prion diseases” Chronic wasting disease / transmissible spongiform encephalopathy symposium, North Dakota Department of Agriculture, Bismarck, ND., 2004
  • "The Design of a Single Round Infectivity Assay for Mason-Pfizer Monkey Virus Using Green Fluorscing Protein" BRIN Student Jessica Hutter-Doane College, 2004
  • "Interspecies Transmission of Prion Diseases", 2004
  • “ Interspecies transmission of prion diseases” Creighton University Medical Center, Osteoporosis research center seminar. Omaha NE., 2004

Research and Scholarship

Research and Scholarship Interests

  • Prion diseases are a group of fatal neurodegenerative diseases that affect humans (e.g. Creutzfeldt-Jacob disease) and animals (e.g. chronic wasting disease). Prion diseases have long subclinical incubation periods of months to decades with a short clinical phase that is characterized by the onset of behavioral, cognitive or motor deficits. Deposition of the abnormal isoform of the prion protein, PrPSc is pathognomonic for prion diseases and its deposition in the central nervous system (CNS) results in neuronal loss and onset of clinical symptoms. PrPSc is an amyloid protein that is resistant to proteolytic degradation and is postranslationally derived from the protease sensitive non-amyloid host encoded prion protein, PrPC. Outside of the CNS, PrPSc deposition occurs in the peripheral nervous system and secondary lymphoreticular system (LRS) tissues such as spleen and lymph nodes. All prion diseases of animals and a majority of prion diseases in humans are due to prion exposure by a peripheral route (e.g. ingestion). Details of the mechanism(s) of prion transport to the CNS are poorly understood. To better define prion transport to the CNS my lab is investigating three areas of prion pathogenesis. First, we are exploring alternative routes of prion entry into the host in an attempt to better define the possible routes that prions can gain access to the CNS. Second, we are investigating the role of the innate immune system in processing and transport of prions to secondary LRS tissues. Finally, we are interested in factors that influence susceptibility of neurons to prion infection and/or replication. The understanding of routes and mechanisms of prion transport will enhance the future development of therapeutic interventions to prevent prion spread to the CNS.

Current Research Projects

Awards and Honors

  • Young Investigator Award, Creighton University, 2005
  • Richard F. Marsh Award for Outstanding Graduate Student Research, University of Wisconsin, 1998