Venkatesh Govindarajan, PhD
Venkatesh Govindarajan, PhD

Venkatesh Govindarajan, PhD

Associate Professor
School of Medicine

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Associate Professor

Secondary Appointment

  • Med. Microbiology & Immunology

Teaching Activity

  • 2007 Spring Advanced Topics in Cell Biology (BMS 703)
  • 2008, 2014 Spring Advanced Topics in Molecular Biology (BMS 704)
  • 2009- present Molecular Cellular Biology Small Groups (IDC 101)
  • 2010 Spring Advanced Topics in Cell Biology (BMS 703)
  • 2010 Spring Developmental Biology (BIO 467)
  • 2013 Fall Current Topics in Medical Microbiology and Immunology (MIC 790)
  • 2014-present Clinical Embryology (CAN626)
  • 2015-present Gross Anatomy (IDC 103)
  • 2016-present Advanced Cell and Molecular Biology (BMS 706)
  • 2016-present Endocrine/Reproductive System (IDC 216)
  • 2016-present Gastrointestinal System (IDC 209)
  • 2016-present Renal-Urinary System (IDC 205)
  • 2017-present Neuroscience PBP506

Education

  • Birla Institute of Technology & Science,M.Sc. & M.M.S.,1987-1992
  • University of Houston,Ph.D.,1992-1997

Publications and Presentations

Articles

  • Kuracha, M. R., Thomas, P., Loggie, B., and Govindarajan, V. Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies PLOS One, 2017, PLoS One, 12(6), p. e0179510., 2017
  • Thomas, P., Kuracha, M. R., Loggie, B., and Govindarajan, V. Carcinoembryonic antigen: A multifunctional molecule in colorectal cancer progression and metastasis Medical Research Archives, Medical Research Archives, 3:(3) , 2017
  • Kuracha, M. R., Thomas, P., Loggie, B., and Govindarajan, V. Patient-derived Xenograft Mouse Models of Pseudomyxoma Peritonei Recapitulates the Human Inflammatory Tumor Microenvironment., Cancer Medicine, 5 (4), 711-719, 2016
  • Judge, S., Thomas, P., Govindarajan, V., Sharma, P., and Loggie, B.  Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment., Annals of Surgical Oncology, 23(5), 1496-1500. , 2015
  • 3. Lohani K, Shetty S, Sharma P, Govindarajan V, Thomas P, Loggie B. Pseudomyxoma Peritonei: Inflammatory Responses in the Peritoneal Microenvironment., Annals of Surgical Oncology, 2014
  • 4. Shetty S., Bathla, L., Govindarajan V., Thomas P. and Loggie B. W. Comparison of visceral sparing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with mitomycin or carboplatin for diffuse malignant peritoneal mesothelioma., American Surgeon, 2014
  • 7. Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A. Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300., Nucleic Acids Research, 2013
  • Kuracha MR, Siefker E, Licht JD, Govindarajan V. Spry1 and Spry2 are necessary for eyelid closure., Developmental Biology, 2013
  • Shetty S, P Thomas, V Govindarajan, P Sharma, G Sirineni, B Loggie. Pseudomyxoma peritonei as a special subset of peritoneal carcinomatosis. Future Medicine, Not Applicable, 2013
  • Shetty S, Thomas P, Ramanan B, Sharma P, Govindarajan V, Loggie B. Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis., J Surg Res, 2013
  • Govindarajan, V.,PA.Overbeek. FGF9 can induce endochondral ossification in cranial mesenchyme., BMC Developmental Biology, 20, 6, 7, 2006
  • Govindarajan, V., WR. Harrison, N. Xiao, D. Liang, PA.Overbeek. Intracorneal positioning of the lens in Pax6-GAL4/VP16 transgenic mice., Molecular Vision, 11, 876-886, 2005
  • Reneker L.W., Xie L., Xu L., Govidarajan, V, Overveek P.A. Activated Ras Induces Lens Epithelial Cell Hyperplasia but not Premature Differentiation., International Journal of Developmental Biology, 48, 879-888, 2004
  • Reneker L.W., L. Xie, L. Xu, V. Govindarajan and P.A. Overbeek. Constitutive Activation of Ras in Ocular Lens Results in Lens Epithelial Cell Over-Proliferation but not Premature Differntiation.
  • Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Bhopal Mohapatra, Manju George, Murali R Kuracha, Matthew Storck, Vimla Band, Venkatesh Govindarajan, Hamid Band. The Endocytic Recycling Regulatory Protein EHD1 Is Required for Ocular Lens Development Submitted to Developmental Biology
  • Judge, S., Shetty, S., Thomas, P., Govindarajan, V., Sharma, P., Loggie, B. Factors associated with survival in patients with Pseudomyxoma Peritonei: influence of signet ring cells. Submitted to Annals of Surgical Oncology

Publications

  • FOXO proteins mediate adaptive resistance to PI3K inhibition in mucinous colorectal cancers.
    Murali R. Kuracha1, Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2
    Department of Surgery1; Department of Biomedical Sciences2; Creighton University School of Medicine, Omaha, NE-68178., American Association for Cancer Research, 138, 2017
  • Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development. Gifford-Truhlsen Conference, University of Nebraska Medical Center, Omaha, Gifford-Truhlesen Conference, 2014
  • Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development., Gordon Research Conference, 2014
  • Kuracha MR, Siefker E, Thomas P, Loggie B, Govindarajan V. Mutant KRAS is necessary for MUC2 production in mucinous peritoneal cancers., St. Albert's day/Creighton University Research day, 2014
  • Massop, D., C Troika, K Lohani, B Loggie, V Govindarajan, P Thomas. The effect of carcinoembryonic antigen on the peritoneal microenvironment in Pseudomyxoma Peritonei. 45th Annual Midwest Student Biomedical Research Forum, Omaha, Midwest Student Biomedical Research Forum, 2014
  • Smith T, M Kuracha, E Seifker, A Sarawagi, P Thomas, B Loggie, V Govindarajan. SAM-pointed domain-containing ETS-like factor (SPDEF) and Mucin2 (MUC2) in Pseudomyxoma Peritonei. 45th Annual Midwest Student Biomedical Research Forum, Omaha, Midwest Student Biomedical Research Forum, 2014
  • Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development., Midwest Student Biomedical Research Forum, 2014
  • Shah P K, K Lohani, S Shetty, P Thomas, P, V Govindarajan, B Natarajan, P Sharma, B Loggie. Signet Ring Cells In Pseudomyxoma Peritonei is a Marker For Poor Survival Academic Surgical Congress, San Diego, CA, Academic Surgical Congress, 2014
  • Arya P, M A Rainey, S Bhattacharyya, M R Kuracha, V Band, V Govindarajan, H Band. An essential role for the endocytic recycling regulator EHD1 in ocular lens development., Not Applicable, 2013
  • Lens and Corneal Epithelial Cells Are Sensitive to GAL4VP16 Epression., Association for Research in Vision & Ophthalmology (ARVO) Annual Meeting, 2005

Presentations

  • FOXO proteins mediate adaptive resistance to PI3K inhibition in mucinous colorectal cancers
    Murali R. Kuracha1, Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2
    Department of Surgery1; Department of Biomedical Sciences2; Creighton University School of Medicine, Omaha, NE-68178.
    American Association for Cancer Research (Poster), 2017
  • ACQUIRED RESISTANCE TO PI3K INHIBITION IN MUCINOUS COLORECTAL CANCERS
    Murali R. Kuracha1,  Peter Thomas1, Brian W. Loggie1, Venkatesh Govindarajan2
     Department of Surgery1; Department of Biomedical Sciences2
    Creighton University School of Medicine, Omaha, NE
    St. Albert's day Research Symposium (Poster), 2017
  • 'Targeted Therapies for Mucinous Peritoneal Malignancies'

    Surgery Grand Rounds, 2016
  • 'Pathobiology of Mucinous Peritoneal Malignancies'

    Department of Biomedical Sciences Seminar, 2015
  • Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Murali R Kuracha, Vimla Band, Govindarajan V., Hamid Band Association for Research in Vision and Ophthalmology (poster) 05/2015, 2015
  • Kuracha, M. R., Thomas, P., Loggie, B. W. and Govindarajan, V. Bilateral blockade of MEK- and PI3K-driven pathways is effective in the treatment of KRAS-mutant mucinous colorectal cancer cells American Association for Cancer Research, Philadelphia (Poster) 04/2015, 2015
  • Kuracha, M. R., Thomas, P., Loggie, B. W. and Govindarajan, V. Targeted therapy for KRAS-mutant mucinous colorectal cancers. Creighton St. Albert’s day Research Symposium (Poster) 04/2015, 2015
  • Judge, S., Shetty, S., Thomas, P., Govindarajan, V., Sharma, P., Loggie, B., Factors associated with survival in patients with Pseudomyxoma Peritonei: influence of signet ring cells. Society of Surgical Oncology Annual Cancer Symposium, Houston (Oral) 03/2015, 2015
  • Nelson, B.Q Kuracha, M. Govindarajan, V. Loggie, B and Thomas, P Carcinoembryonic Antigen (CEA) Induced Proliferation and Angiogenesis in Pseudomyxoma Peritonei 46th Annual Midwest Student Biomedical Research Forum (poster) 02/2015, 2015
  • Priyanka Arya, Mark A Rainey, Sohinee Bhattacharyya, Murali R Kuracha, Vimla Band, Govindarajan, V., Hamid Band The endocytic recycling regulator EHD1 is required for ocular lens development 46th Annual Midwest Student Biomedical Research Forum (MSBRF) (poster) 02/2015, 2015
  • Judge, S. Shetty, S. Thomas, P. Govindarajan, V. Sharma, P. and Loggie, B. Factors associated with survival in patients with Pseudomyxoma peritonei: Influence of signet ring cells. American College of Surgeons Clinical Congress (Oral) 09/2014, 2014
  • Pathobiology of Mucinous Peritoneal Carcinomatosis Grand Rounds, Department of Surgery Creighton Medical School, 2014
  • Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, 2006
  • Department of Ophthalmology, University of Nebraska Medical Center, Omaha, 2005
  • Abstract titled: Lens and Corneal Epithelial Cells Are Sensitive to GAL4VP16 Expression. Presented at the Associciation for Research in Vision & Ophthalmology (ARVO) Annual Meeting in Ft Lauderdale, FL., 2005

Research and Scholarship

Research and Scholarship Interests

  • Mucinous colorectal cancers, Pseudomyxoma peritonei, targeted therapy

Current Research Projects

  • Sporadic colorectal cancers comprise a heterogeneous group of tumors and a significant proportion (10-15%) are of the mucinous subtype (defined as >50% of the tumor).  Our research is focused on mucinous colon adenocarcinoma (MCA) and pseudomyxoma peritonei (PMP), two cancers arising from mucinous neoplasms of the colon and appendix that show a propensity to disseminate throughout the abdominal cavity.  MCAs are most frequently found in the proximal colon.  The etiology of MCA is poorly understood.  MCAs show a different spectrum of molecular and genetic alterations than nonmucinous CRCs (excessive mucin production, higher microsatellite instability (MSI-H), higher CpG Island Methylator Phenotype (CIMP-H), higher LINE-1 methylation and higher mutation rates for KRAS, BRAF and PIK3CA).  Clinically, MCAs present at a more advanced stage, are more prone to peritoneal dissemination and lymph node metastasis and generally have a poor prognosis.  Pseudomyxoma peritonei (PMP) is a related mucinous neoplasm that arises in the appendix and is prone to peritoneal dissemination.  PMP presents as bulky, multifocal tumor implants within the peritoneal cavity and a characteristic feature of this malignancy is the overproduction of mucinous ascites in patients with advanced disease.  Therapeutic options are limited for PMP patients. Aggressive cytoreductive surgery (reduction of all macroscopic lesions) in conjunction with warmed intraperitoneal chemotherapy (circulation of warmed chemotherapeutic agents within the peritoneal cavity) has been the only treatment intervention shown to improve patient outcomes and facilitate long-term survival in selected patients.  Nevertheless, not all patients respond to treatment and additional therapies that are more effective and less toxic than current approaches are badly needed.  In the laboratory, we employ in vitro (cell and tissue culture), in vivo (cell line-derived and patient-derived xenograft mouse models) and in silico (bioinformatics) approaches to define critical genes and signaling pathways that drive neoplastic growth of these mucinous cancers which in turn, is expected to allow the identification of novel targets for therapy. 

    We have access to the MCA and PMP patient population through the peritoneal neoplastic disease program (directed by Dr. Brian Loggie, surgical oncologist) at Creighton.  In addition to the surgical oncologist, our translational working group includes a pathologist, a pharmacist and a biochemist.