Shashank Dravid, PhD
Shashank Dravid, PhD

Shashank Dravid, PhD

Associate Professor
School of Medicine

Academic Appointments

Department

  • Pharmacology

Position

  • Associate Professor

Education

  • University of Georgia,Ph.D.,1999-2003
  • B.V.Sc. & A. H. 1994-1999

Publications and Presentations

Books

  • Yadav R, Gupta SC, Hillman BG, Bhatt JM, Stairs DJ, Dravid SM Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors, Not Applicable, 7(3):e32969, 2012

Articles

  • Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity. Gupta SC, Yadav R, Pavuluri R, Morley BJ, Stairs DJ, Dravid SM, Neuropharmacology, 2015 Jun;93, 274-84, 2015
  • Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy Parameswaran S, Dravid SM, Teotia P, Krishnamoorthy RR, Qiu F, Toris C, Morrison J, Ahmad I, Stem Cells, Jun;33(6), 1743-58, 2015
  • Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ., Molecular Brain, Feb 3;8:7, 2015
  • Spatially selective photoconductive stimulation of live neurons. Campbell J, Singh D, Hollett G, Dravid SM, Sailor MJ, Arikkath J., Frontiers in Cellular Neuroscience, 8:142, doi: 10.3389/fncel.2014.00142., 2014
  • GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. Suryavanshi PS, Ugale RR, Yilmazer-Hanke D, Stairs DJ, Dravid SM, British Journal of Pharmacology, 171(3), 799-809, 2014
  • Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat. Gupta SC, Hillman BG, Prakash A, Ugale RR, Stairs DJ, Dravid SM., European Journal of Neuroscience, 37(11), 1811-22, 2013
  • Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning Yadav R, Hillman BG, Gupta SC, Suryavanshi P, Bhatt JM, Pavuluri R, Stairs DJ, Dravid SM, PLoS One, 8(4), e60785, 2013
  • Effect of ifenprodil on GluN1/GluN2B N-methyl-D-aspartate receptor gating. Bhatt JM, Prakash A, Suryavanshi PS, Dravid SM, Molecular Pharmacology, 83(1), 9-21, 2013
  • κ-Opioid receptor inhibition of calcium oscillations in spinal cord neurons. Kelamangalath L, Dravid SM, George J, Aldrich JV, Murray TF., Molecular Pharmacology, 79:6, 1061-71, 2011
  • Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory Hillman BG, Gupta SC, Stairs DJ, Buonanno A, Dravid SM, Neurobiology of Learning and Memory, 95:4, 404-14, 2011
  • Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate delta 1 receptor Yadav R, Rimerman R, Scofield MA, Dravid SM, Brain Res, 1382, 1-8, 2011
  • Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. Jabba SV, Prakash A, Dravid SM, Gerwick WH, Murray TF., Journal of Pharmacology and Experimental Therapeutics, 332(3), 698-709, 2010
  • Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. Dravid SM, Burger PB, Prakash A, Geballe MT, Yadav R, Le P, Vellano K, Snyder JP, Traynelis SF., Journal of Neuroscience, 30(7), 2741-54, 2010
  • George J, Dravid SM, Prakash A, Xie J, Peterson J, Jabba SV, Baden DG, Murray TF. Title: Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons., Journal of Neuroscience, 29 (10), 3288-301, 2009
  • Dravid SM, Prakash A, Traynelis SF. Title: Activation of recombinant NR1/NR2C NMDA receptors., Journal of Physiology, 486 (18), 4425-39, 2008
  • Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS. ”Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.”, Proceedings of the National Academy of Sciences, 104(35), 14116-21, 2007
  • Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. Dravid SM, Erreger K, Yuan H, Nicholson K, Le P, Lyuboslavsky P, Almonte A, Murray E, Mosely C, Barber J, French A, Balster R, Murray TF, Traynelis SF., Journal of Physiology, 581(Pt 1), 107-28, 2007
  • Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. Erreger K, Geballe MT, Dravid SM, Snyder JP, Wyllie DJ, Traynelis SF., Journal of Neuroscience, 25(34), 7858-66, 2005
  • Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3. Yuan H, Erreger K, Dravid SM, Traynelis SF., Journal of Biological Chemistry, 280(33), 29708-16, 2005
  • Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. Erreger K, Dravid SM, Banke TG, Wyllie DJ, Traynelis SF., Journal of Physiology, 563(2), 345-58, 2005
  • Brevetoxin augments NMDA receptor signaling in murine neocortical neurons. Dravid SM, Baden DG, Murray TF., Brain Res, 1031(1), 30-8, 2005
  • Protons trap NR1/NR2B NMDA receptors in a nonconducting state. Banke TG, Dravid SM, Traynelis SF., Journal of Neuroscience, 25(1), 42-51, 2005
  • Brevetoxin activation of voltage-gated sodium channels regulates Ca dynamics and ERK1/2 phosphorylation in murine neocortical neurons. Dravid SM, Baden DG, Murray TF., Journal of Neurochemistry, 89(3), 739-49, 2004
  • Spontaneous synchronized calcium oscillations in neocortical neurons in the presence of physiological [Mg(2+)]: involvement of AMPA/kainate and metabotropic glutamate receptors Dravid SM, Murray TF., Brain Res, 1006(1), 8-17, 2004
  • Fluorescent detection of Ca2+-permeable AMPA/kainate receptor activation in murine neocortical neurons Dravid SM, Murray TF., Neuroscience Letters, 35(3), 145-8, 2003

Presentations

  • Gating effects of a novel allosteric modulator at GluN1/GluN2A NMDA receptors 1. Chopra D. A., Irvine M. W., Jane D. E., Monaghan D. T., Dravid S. M., 2015
  • The NMDA receptor GluN2C subunit regulates behavioral and cellular phenotypes relevant to schizophrenia 2. Ravikrishnan A., Hillman B. G., Gupta S. C., Pavuluri R., Stairs D. J., Dravid S. M, 2014
  • Society for Neuroscience Annual meeting. Poster presentation Title: Glutamate delta-1 receptor regulates dendritic spine morphology and density in cortico-limbic circuit *S. C. GUPTA1, P. S. SURYAVANSHI1, B. J. MORLEY2, S. M. DRAVID1;, 2013
  • Society for Neuroscience Annual meeting. Poster presentation Title: Voltage-gated sodium channel activator enhancement of immature cerebrocortical neuron development requires both the N-methyl-D-aspartate receptor 2B (GluN2B) and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) *S. MEHROTRA, S. M. DRAVID, T. F. MURRAY, 2013
  • Society for Neuroscience Annual meeting. Poster presentation Title: Best1-mediated astrocytic glutamate lowers the threshold of synaptic plasticity *J. LEE1, H. PARK1, K.-S. HAN1, J. SEO2, S. M. DRAVID3, J. WOO1, H. CHUN1, S. CHO2, T. KIM1, H. AN1, B.-E. YOON1,4, R. BERLINGUER-PALMINI5, G. MANNAIONI6, S. F. TRAYNELIS7, S. CHOI2, C. LEE1;, 2013
  • Targeting the NMDA receptor hypofunction hypothesis of schizophrenia: Emerging clues from genetic models and drug discovery efforts Winter Conference on Brain Research Panel Chair, 2013
  • Protease activated receptor regulates migration and invasion of glioblastoma via transactivation of EGFR 3. Gupta S.C., Bandyopadyay B., Prakash A., Yadav R. and Dravid S.M. Society for Neuroscience 2012, 2012
  • Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficits in contextual fear conditioning. 2. Suryavanshi P.S., Yadav R., Hillman B.G., Gupta S.C., Stairs D.J. and Dravid S.M. Society for Neuroscience 2012, 2012
  • INBRE "Ionotropic glutamate receptors: Therapeutic potential in neuropsychiatric disorders", 2012
  • 1. Hillman B.G., Stairs D.J. and Dravid S.M. (2012) Role of GluN2C-containing receptors in rodent schizophrenia-like phenotypes. FASEB J, March 29, 26:1045.5, 2012
  • 2. Ugale R.R., Hillman B.G., Gupta S.C., Suryavanshi P., Stairs D.J. and Dravid S.M. (2012) Role of NMDA receptor subtype in regulation of central amygdala. FASEB J, March 29, 26:lb574., 2012
  • 3. Dravid S.M., Mannioni G., Lee J., Wahl P., Lee C.J. and Traynelis S.F. (2012). Protease activated receptor-1 (PAR1) control of glutamate time course in the synaptic cleft. FASEB J, March 29, 26:lb577., 2012
  • 4. Gupta S.C., Hillman B.G., Prakash A., Stairs D.J. and Dravid S.M. (2011). D-cycloserine potentiates fear extinction-induced ERK activation in prefrontal cortex and lateral nucleus of central amygdala. Prog No. 762.17. SFN 2011 online., 2011
  • 5. Murray T.F., Kelamangalath L., George J., Dravid S.M. and Aldrich J.V. (2011). Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons. Prog No. 341.24. SFN 2011 online., 2011
  • 6. Hillman B.G., Gupta S.C., Suryavanshi P.S., Stairs D.J. and Dravid S.M. (2011). Regulation of inhibitory tone in the central amygdala by NMDA receptor GluN2C subunit. Gordon Research Conferences. Amygdala in health and disease., 2011
  • Adopting the orphan glutamate delta-1 receptor at Indian Institute of Sciences, Bangalore, 2011
  • The orphan glutamate delta-1 receptor: potential role in central nervous system and mental disorders NIMHANS, Bangalore, India, 2011
  • Ablation of nr2c receptor models negative symptoms of schizophrenia B. HILLMAN1, S. GUPTA1, D. STAIRS2, S. DRAVID1, 2010
  • Effects of Ifenprodil on NR1/NR2B NMDA receptor gating J. M. BHATT1, A. PRAKASH1, *S. DRAVID2;, 2010
  • Kappa opioid receptor regulation of spontaneous calcium oscillations in embryonic spinal cord neurons L. KELAMANGALATH1, S. DRAVID1, J. ALDRICH2, T. F. MURRAY, 2010
  • Functional study of ionotropic glutamate delta-1 receptor R. YADAV, M. SCOFIELD, R. A. RIMERMAN, S. M. DRAVID, 2010
  • Poster Presentation: Society for Neuroscience annual meeting. Structure-function study of ionotropic glutamate delta-1 receptor. R. YADAV, M. ROENFELD, M. SCOFIELD, S. DRAVID, 2009
  • Poster presentation: Society for Neuroscience annual meeting. Acquisition of fear and extinction in an NR2C knock-out B. HILLMAN, S. DRAVID, 2009
  • Tuesday Night Neuroscience "Adopting the orphan glutamate delta receptor.", 2008
  • Poster presentation S. M. DRAVID, M. T. GEBALLE, J. P. SNYDER, S. F. TRAYNELIS Residue at dimer interface of NR1/NR2C ligand binding domain control the relative efficacy of D-cycloserine, 2007
  • Departmental seminar "Modulation of Glutamate Receptors", 2007

Research and Scholarship

Research and Scholarship Interests

  • Glutamate is the major excitatory neurotransmitter in the central nervous system. The family of glutamate receptors play a critical role in synaptic plasticity and learning and memory. We are interested in understanding the roles of glutamate receptors and in particular N-methyl-D-aspartate (NMDA) and glutamate delta receptors in the central nervous system. The eventual goal is apply this undestanding to develop therpeuatics to treat severe neuropsychiatric and neurological disorders.