Timothy A. Simeone, PhD
Timothy A. Simeone, PhD

Timothy A. Simeone, PhD

Associate Professor
Program Director, M.S. and Ph.D. students
School of Medicine, Omaha Campus

Academic Appointments

Department

  • Pharmacology and Neuroscience

Position

  • Associate Professor

Publications and Presentations

Articles

  • Carbamazepine Reduces Sharp Wave-Ripple Complexes and Exerts Synapse-Specific Inhibition of Neurotransmission in Ex Vivo Hippocampal Slices, Brain Sciences, 11, 787, 2021
  • Changes in lipid profiles of epileptic mouse model, Metabolomics, 16, 106, 2020
  • Aberrant energy metabolism and redox balance in seizure onset zones of epileptic patients, Journal of Proteomics, 223, 103812, 2020
  • Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death in epilepsy (SUDEP): The contribution of orexin, Epilepsia, 61, 572-588, 2020
  • Jobst BC, Ben-Menachem E, Chapman KE, Fu A, Goldman A, Hirsch LJ, Jehi LE, Kossoff EH, Plueger M, Rho JM, Schevon CA, Shinnar S, Sperling MR, Simeone TA, Wagner JL, Lado F. Highlights From the Annual Meeting of the American Epilepsy Society 2018., Epilepsy Currents, 2019
  • Knowles S, Budney S, Deodhar M, Matthews SA, Simeone KA, Simeone TAKetogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2., Epilepsy Research, 147, 71-74, 2018
  • Warren TJ, Simeone TA, Smith DD, Grove R, Adamec J, Samson KK, Roundtree HM, Madhavan D, Simeone KA. Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders., Neurobiology of Disease, 114, 45-52, 2018
  • Simeone TA, Simeone KA, Stafstrom CE, Rho JM. Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?, Neuropharmacology, 133, 233-241, 2018
  • Simeone KA, Hallgren J, Bockman CS, Aggarwal A, Kansal V, Netzel L, Iyer SH, Matthews SA, Deodhar M, Oldenburg PJ, Abel PW, Simeone TARespiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy., Epilepsia, 59(2), 345-357, 2018
  • Iyer SH, Matthews SA, Simeone TA, Maganti R, Simeone KA. Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy., Epilepsia, 59(1), 92-105, 2018
  • Simeone TA, Matthews SA, Simeone KA. Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone., Epilepsia, 58(8), 1440-1450, 2017
  • Simeone TA, Simeone KA, Rho JM. Ketone Bodies as Anti-Seizure Agents., Neurochemical Research, 42(7), 2011-2018, 2017
  • Simeone TA, Rho JM. Antiepileptic Drugs: Antiepileptic Drug Mechanisms. In: Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier; 2017. ISBN 9780128093245, Elsevier, 2017
  • Simeone TA, Matthews SA, Samson KK, Simeone KA.Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy., Experimental Neurology, 287(Pt 1), 54-64, 2017
  • Simeone TA. Ketogenic Diet and PPARgamma. In Masino SA (Ed) Ketogenic diet and metabolic therapies: expanded roles in health and disease. New York: Oxford University press, 2017:167-185., Oxford University Press, 167-185, 2017
  • Simeone KA, Matthews SA, Rho JM, Simeone TA.Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy., Epilepsia, 57(8), e178-182, 2016
  • Roundtree HM, Simeone TA, Johnson C, Matthews SA, Samson KK, Simeone KA. Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-null Mice., Sleep, 39(2), 357-368, 2016
  • Simeone KA, Johnson CJ, Samson KK, Roundtree HM, Simeone TA, Tarhok LA. Sleep In Masino & Boison (Eds), Brain Homeostasis. Oxford Press; 2015.
     , Oxford University Press, 2015
  • Kim DY, Simeone KA, Simeone TA, Pandya JD, Wilke JC, Ahn Y, Geddes JW, Sullivan PG, Rho JM.2. Ketone bodies mediate antiseizure effects through mitochondrial permeability transition., Annals of Neurology, doi: 10.1002/ana.24424, 2015
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv1.1alpha knockout mice., Epilepsia, 55(5), e44-49, 2014
  • Simeone KA, Matthews SA, Samson KK, Simeone TA. Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures., Experimental Neurology, 251, 84-90, 2014
  • Simeone TA, Simeone KA, Samson KK, Kim DY, Rho JM (2013) Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices., Neurobiology of Disease, 54, 68-81, 2013
  • Simeone TA, Wilcox KS, White HS. cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABAA receptors, Epilepsy Research, 9, 176-179, 2011
  • Simeone TA, Wilcox KS, White HS. Topirmate modulation of β1- and β3-homomeric GABAA receptors., Pharmacological Research, 64:1, 44-52, 2011
  • Simeone KA, Sabesan S, Kim do Y, Kerrigan JF, Rho JM, Simeone TA L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue., Epilepsia, 52(3), 531-540, 2011
  • Simeone TA. Mechanisms of Antiepileptic Drug Action. In: Epilepsy: Mechanisms, Models, and Translational Perspectives, Rho JM (Ed.), Sankar R (Ed.), Stafstrom CE (Ed.). CRC Press, Taylor & Francis Group LLC., Not Applicable, 123-141, 2010
  • T.A. Simeone and J.M. Rho. Antiepileptic Drug Mechanisms. P.A. Schwartzkroin (ed.), Oxford:Academic Press, Not Applicable, 1, 59-66, 2009

Publications

  • Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity., 64th Annual Meeting of the American Epilepsy Society, 2010
  • Simeone KA, Rho JM, Samson K, Simeone TA. Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice., 64th Annual Meeting of the American Epilepsy Society, 2010

Presentations

  • Kostansek JA IV, Simeone TA, Simeone KA. The Role of Orexin in Hippocampal Physiology. 52nd Annual Midwest Student Biomedical Research Forum, Omaha, NE, 2021., 2021
  • Heruye SH, Warren TJ, Simeone KA, Simeone TA. Physiological Concentrations of Ascorbic Acid Impair Basal Synaptic Transmission and Molecular Correlates of Memory. 52nd Annual Midwest Student Biomedical Research Forum. Omaha, NE, 2021., 2021
  • Yeh M, Deodhar M, Simeone, KA Simeone TA. Characterizing Neurons Differentiated From NTera2/CL.D1 (NT2) Cells. 52nd Annual Midwest Student Biomedical Research Forum, Omaha, NE,, 2021., 2021
  • Yeh M, Deodhar M, Simeone KA, Simeone TA. Characterizing Neurons Differentiated From NTera2/CL.D1 (NT2) Cells. Asian Pacific American Medical Student Association National Conference, Virtual, 2021., 2021
  • Yeh M, Deodhar M, Simeone KA, Simeone TA. Characterizing an AraC-Differentiated NT2 Population. 2020 Creighton Neuroscience Symposium, Omaha, NE, 2020., 2020
  • Heruye SH, Warren TJ, Simeone KA, Simeone TA. Concentration dependent effect of ascorbic acid on molecular correlates of memory. 2020 Creighton Neuroscience Symposium, Omaha, NE, 2020., 2020
  • Kostansek JA IV, Simeone TA, Simeone KA. The Role of Orexin in Hippocampal Physiology. 2020 Creighton Neuroscience Symposium, Omaha, NE, 2020., 2020
  • Heruye, SH., Warren, TJ., Simeone, KA, Simeone TA. Effects of complex I of the electron transport chain on different forms of synaptic plasticity. 51st Annual Midwest Student Biomedical Research Forum, Omaha, NE, 2020, 2020
  • Yeh M, Deodhar M, Simeone KA, Simeone TA. Characterizing Neurons Differentiated From NTera2/CL.D1 (NT2) Cells. 51st Annual Midwest Student Biomedical Research Forum, Omaha, NE,, 2020., 2020
  • Heruye S, Warren T, Simeone KA, Simeone TA. Effects of Complex I of the Electron Transport Chain on Synaptic Plasticity. Park City Epilepsy Meeting, Park City, UT, 2019., 2019
  • Warren TJ, Simeone TA, Simeone KA. Excessive Silencing of Orexin Neurons by Protons in a Mouse Model of Epilepsy and SUDEP. American Epilepsy Society, New Orleans, LA, 2018., 2018
  • 6th Global Symposium on Ketogenic Therapies, Jeju, Korea. Title: The role of PPARgamma in Epilepsy and KD efficacy., 2018
  • Spring Brain conference, Sedona, AZ. Title: Insights into Antiseizure Mechanisms Through the Lens of Dietary Therapies., 2018

  • Gavrilovici, Simeone TA, Rho JM. Hippocampal interneuron dysfunction in the Kcna1-null mouse model of epilepsy. American Epilepsy Society, Washington, D.C., 2017.
     , 2017

  • Warren TJ, Samson K, Roundtree H, Simeone TA, Simeone KA. Differences in adenosine tone and inhibition in the hypothalamus and hippocampus of Kcna1 KO mice. American Epilepsy Society, Washington, D.C., 2017.
     , 2017

  • Iyer S, Matthews S, Maganti R, Simeone TA, Simeone KA. Disrupted rest-active rhythms precedes sudden death in epilepsy Kv1.1 knockout mouse model. American Epilepsy Society, Washington, D.C., 2017.
     , 2017

  • Knowles S, Budney, Mattews SA, Deodhar M, Simeone KA, Simeone TA. The ketogenic diet regulates catalase via the transcription factor peroxisome proliferator activated receptor gamma 2. Society for Neuroscience annual meeting, Washington, D.C., 2017.
     , 2017

  • Deodhar M, Thomas B, Adamian L, Matthews SA, Simeone KA, Simeone TA. Pharmacoresponsivness of seizures and sleep-wake patterns of Kcna1-null mice, a model of temporal lobe epilepsy with co-morbid sleep disorders to conventional anti-seizure drugs (ASDs). Society for Neuroscience annual meeting, Washington, D.C., 2017.
     , 2017

  • Knowles S, Budney S, Kansal V, Mattews SA, Simeone TA. The Role of Catalase in the Ketogenic Diet. St. Albert's Research Day, Creighton University, Omaha, NE, 2017.
     , 2017
  • Budney S, Knowles S, Kansal V, Mattews SA, Simeone TA. Elucidating the Effects of PPARγ2 Mediated by the Ketogenic Diet in Refractory Epilepsy. Midwest Student Biomedical Research Forum, Omaha, NE, 2017.
     , 2017

  • Adamian L, Matthews SA, Simeone TA, Simeone KA. Phenobarbital improves sleep in Kcan1-null mice. Midwest Student Biomedical Research Forum, Omaha, NE, 2017.
     , 2017

  • Thomas B, Matthews SA, Simeone TA. Kcna1-null mice, a model of refractory epilepsy? Midwest Student Biomedical Research Forum, Omaha, NE, 2017.
     , 2017
  • American Epilepsy Society annual meeting, Houston, TX. Dietary Therapy Special Interest Group. Title: PPARgamma and the Ketogenic Diet., 2016

  • Deodhar M, Matthews SA, Simeone TA. Characterization of a Modified Flurothyl Kindling Model. American Epilepsy Society, Houston, TX, 2016.
     , 2016
  •  Iyer S, Aggarwal A, Matthews SA, SimeoneTA, Simeone KA. Does progressive elevation in orexinergic activity promote bradycardia in Kv1.1 KO mice, a model of SUDEP? American Epilepsy Society, Houston, TX, 2016.

    , 2016
  • 5th Global Symposium on Ketogenic Therapies, Banff, Alberta, Canada. Investigator’s Workshop session on Basic Research Highlights. Title: PPARgamma and the Ketogenic Diet., 2016
  • Simeone TA, Matthews SA, Simeone KA. Synergistic antiseizure effects of the ketogenic diet and the Type II Diabetes drug pioglitazone on acute flurothyl–induced seizures. 5th Global Symposium on Ketogenic Therapies, Banff, Alberta, Canada, 2016.
     , 2016
  • Simeone KA, Matthews SA, Rho JM, Simeone TA. Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. 5th Global Symposium on Ketogenic Therapies, Banff, Alberta, Canada, 2016.
     , 2016
  • American Epilepsy Society annual meeting, Philadelphia, PA. Investigator’s Workshop session on Targeting Mitochondrial Function as an Antiseizure Strategy. Title: Contributions of Mitochondrial Dysfunction to Network Hyperexcitability., 2015

  • Deodhar M, Matthews SA, Simeone KA, Simeone TA. Development of a Modified Flurothyl Kindling Model. American Epilepsy Society, Philadelphia, PA, 2015.
     , 2015

  • Aggarwal A, Deodhar M, Simeone KA, Simeone TA. Infiltration of Leukocytes into the Brain of Epileptic Kcna1-null Mice. American Epilepsy Society, Philadelphia, PA, 2015.
     , 2015

  • Gavrilovici C, Simeone TA, Rho JM. Interneuronopathy in the Kcna1-null mouse model of epilepsy. American Epilepsy Society, Philadelphia, PA, 2015.
     , 2015

  • Kansal V, Aggarwal A, Matthews SA, Oldenburg P, SimeoneTA, Simeone KA. A Longitudinal Study of Respiratory Function of Epileptic Kcna1-Null Mice Using Non-Invasive Airway Mechanincs (NAM). American Epilepsy Society, Houston, TX, 2016.
     , 2015
  • 3. Iyer S, Matthews SA, Samson KK, Simeone KA, Simeone TA. Antiseizure Effects Of Ketogenic Diet Are Mediated Via Regulation Of Brain PPAR-gamma, A Nutritionally Responsive Transcription Factor. ADD Program Symposium, Park City, UT, May, 2015., 2015
  • 1. Roundtree HM, Matthews SA, Johnson CC, Simeone TA, Simeone KA. Effects of Dual Orexin Receptor Antagonism on Sleep and Seizures in the Kcna1-null Model of Epilepsy. ADD Program Symposium, Park City, UT, May, 2015., 2015
  • 2. Deodhar M, Aggarwal A, Simeone TA, Simeone KA. Preliminary evidence of adaptive immune cell infiltration into the brain of a genetic model of chronic epilepsy. ADD Program Symposium, Park City, UT, May, 2015., 2015
  • 2015 Creighton University School of Medicine, Omaha, NE. Department of Biomedical Sciences. Research Rounds Seminar Series. Title: The role of brain PPARs in the anti-seizure efficacy ketogenic diet., 2015
  • University of Utah School of Pharmacy, Salt Lake City, UT. Department of Pharmacology and Toxicology. Title: Ketogenic Diet Therapy for Epilepsy: Searching for a Mechanism., 2015
  • 2015 Creighton University School of Medicine, Omaha, NE. Department of Pharmacology. Research Rounds Seminar Series. Title: Optogenetic Use in Epilepsy: examples from the literature., 2015
  • Neuroscience Journal Club. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy., 2015
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. Brain PPARgamma mediates ketogenic diet anti-seizure efficacy. American Epilepsy Society, Seattle, WA, 2014., 2014
  • 2014 American Epilepsy Society annual meeting, Seattle, WA. Ketogenic Diet Special Interest Group. Title: Is the ketogenic diet a disease modifying therapy for Epilepsy? The basic science perspective., 2014
  • 2014 Society for Neuroscience annual meeting, Washington D.C. Nanosymposium. Title: Brain PPARgamma contributes to the anti-seizure efficacy of the ketogenic diet., 2014
  • Simeone KA, Roundtree HM, Samson KK, Simeone TA. Consequences of seizure propagation to the sleep regulating lateral hypothalamus. Society for Neuroscience, Washington D.C., 2014., 2014
  • 2014 University of Nebraska Medical Center, Omaha, NE. Department of Neurological Sciences. Current and Future Directions for Translational Epilepsy Research Seminar Series. Title: PPARgamma involvement in Ketogenic Diet Therapy for Refractory Epilepsy., 2014
  • “Seizure Propagation to the Lateral Hypothalamus and Sleep-Wake Triggers” Oregon Health Science University, Portland, OR, 2014
  • “Mechanisms of Hippocampal Network Hyperexcitability in Kv1.1alpha Knockout Mice” Department of Pharmacology Research Rounds, Creighton University, Omaha, NE, 2014
  • Samson KK, Simeone KA, Rho JM, Simeone TA. Effects of Ketogenic Diet and Constituents on Pathologic Sharp Waves and High Frequency Oscillations. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Simeone KA, Stephanie A. Matthews SA, Samson KK, Simeone TA. A Novel Mitochondria-targeted Anticonvulsant Treatment. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Roundtree HM, Samson KK, Simeone TA, Simeone KA. Evidence of Pathology in the Lateral Hypothalamus: A Connection Between Sleep Disorder and Epilepsy in the Kv1.1 Knock-Out Mouse. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Ranade NP, Samson KK, Simeone KA, Simeone TA. Anticonvulsant Effects of Pioglitazone on High Potassium Seizure-Like Events in in vitro Hippocampal Slices. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity. Creighton University, The Faculty Club Research at Center Stage, October, 2012., 2012
  • “High Frequency Oscillations and Epilepsy: the State of Our Knowledge” Neurology Grand Rounds, CME credit, Creighton University School of Medicine, Omaha, NE, March 2012, 2012
  • Simeone TA, Simeone KA, Samson KK, Rho JM. Loss of Kv1.1 Alpha Subunit Alters Hippocampal Sharp Wave-Ripple Complexes and Promotes the Emergence of Pathologic Fast Ripples. American Epilepsy Society, Baltimore, MD., 2011
  • 2. Simeone KA, Roundtree HM, Samson KK, Simeone TA. Pathologic Hypocretin Circuitry: A Novel Mechanism of Sleep Disorders Associated with Epilepsy in Kv1.1 Knock-Out Mice. American Epilepsy Society, Baltimore, MD., 2011
  • Normal Emergent Properties Hijacked by an Epileptic Brain. St. Albert's Day, Creighton University School of Medicine, 2011
  • 1. Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity. American Epilepsy Society, San Antonio, TX, 2010
  • UNL Department of Biochemistry & Redox Biology Center. “Epilepsy and Emergent Properties of Neuronal Networks”., 2010
  • Normal Emergent Properties Hijacked by an Epileptic Brain. Faculty Club, Creighton University School of Medicine, 2010
  • “Epilepsy: dysregulation of emergent properties of neuronal networks.” Dept of Pharmacology, UNMC, Omaha, NE, 2010
  • “Epilepsy: Dysregulation of Emergent Properties of Neuronal Networks,” presented to the Molecular & Cellular Biology Faculty Research Group, 2009

Awards and Honors

  • 20160199364, Seizure treatment compositions and methods, 2016
  • 20150164857, Seizure Therapy, 2016
  • Intramural Research Award, 2014