Kristina A. Simeone, PhD
Kristina A. Simeone, PhD

Kristina A. Simeone, PhD

Associate Professor
Director, Master's in Neuroscience Program
School of Medicine, Omaha Campus

Academic Appointments

Department

  • Pharmacology and Neuroscience

Position

  • Associate Professor

Publications and Presentations

Articles

  • Bolton JL, Short AK, Simeone KA, Daglian J, Baram TZ. Programming of Stress-Sensitive Neurons and Circuits by Early-Life Experiences., Frontiers in Behavioral Neuroscience, 18, 13-30, 2019
  • Knowles S, Budney, Deodhar M, Matthews SA, Simeone KA, Simeone TA. Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2., Epilepsy Research, 147, 71-74, 2018
  • Warren TJ, Simeone TA, Smith DD, Grove R, Adamec J, PhDc, Samson KK, Roundtree HM, Madhavan D, Simeone KA. Adenosine has two faces: regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders., Neurobiology of Disease, 114, 45-52, 2018
  • Simeone TA, Simeone KA, Stafstrom CE, Rho JM. Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?, Neuropharmacology, 133, 233-241, 2018
  • Singh-Taylor A, Molet J, Jiang S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J, Chen Y, Mortazavi A, Baram TZ.NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience., Molecular Psychiatry, 23, 648-657, 2018
  • Simeone KA, Hallgren J, Bockman CS, Aggarwal A, Kansal V, Netzel L, Iyer SH, Matthews SA, Deodhar M, Oldenburg PJ, Abel PW, Simeone TA. Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden death in epilepsy., Epilepsia, 59, 345-357, 2018
  • Iyer SH, Matthews SA, Simeone TA, Maganti R, Simeone KA. Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy., Epilepsia, 59, 92-105, 2018
  • Iyer SH, Matthews SA, Simeone TA, Maganti R, Simeone KA. Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of SUDEP., Epilepsia, 59, 92-105, 2018

  • Simeone TA, Matthews SA, Simeone KA. Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone. , Epilepsia, 58, 1440-1450, 2017
  • Simeone TA, Simeone KA, Rho JM. Ketone Bodies as Anti-Seizure Agents., Neurochemical Research, 42, 2011-2018, 2017
  • Kerrigan JF, Parsons A, Tsang C, Simeone K, Coons S, Wu J.Hypothalamic hamartoma: Neuropathology and epileptogenesis., Epilepsia, 2, 22-31, 2017
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. Regulation of brain PPARgamma contributes to ketogenic diet anti-seizure efficacy., Experimental Neurology, 57, 178-182, 2017
  • Simeone KA, Matthews SA, Rho JM, Simeone TA. Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy., Epilepsia, 57, 178-82, 2016
  • Roundtree HM, Simeone TA, Johnson CJ, Matthews SA, Samson KK, Simeone KA. Orexin receptor antagonism improves sleep and reduces seizures in Kcna1-null mice., Sleep, 39, 357-368, 2016
  • Simeone KA, Johnson CJ, Samson KK, Roundtree HM, Simeone TA, Tarhok LA. Sleep In Masino & Boison (Eds), Brain Homeostasis. Oxford Press., Oxford University Press, 2015
  • Kim DY*, Simeone KA*, Simeone TA, Pandya J, Wilke J, Ahn Y, Geddes J, Sullivan PG, Rho JM (2015). Ketone Bodies Mediate Anti-Seizure Effects Through mPT, Annals of Neurology, doi: 10.1002/ana.24424. , [Epub ahead of print]., 2015
  • In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv 1.1α knockout mice. Simeone TA, Samson KK, Matthews SA, Simeone KA, Epilepsia, 55(5), 44-49, 2014
  • Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Simeone KA, Matthews SA, Samson KK, Simeone TA., Experimental Neurology, 251, 84-90, 2014
  • Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices. Simeone TA, Simeone KA, Samson KK, Kim do Y, Rho JM., Neurobiology of Disease, 54, 68-81, 2013
  • Simeone TA, Simeone KA, Samson KK, Kim DY, Rho JM (2013) Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices., Neurobiology of Disease, 54, 68-81, 2013
  • Hypothalamic hamartomas: neuropathological features with and without prior gamma knife radiosurgery. Kerrigan JF, Parsons A, Rice SG, Simeone KA, Shetter AG, Abla AA, Prenger E, Coons SW., Not Applicable, 91(1), 2013
  • L-Type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue. Simeone KA, Sabesan S, Kim do Y, Kerrigan JF, Rho JM, Simeone TA., Epilepsia, 52, 531-540, 2011
  • Chan YM, K.A. Fenoglio-Simeone, S. Paraschos, L. Muhammad, M.M. Troester, Y.Y. Ng, R.E. Johnsonbaugh, S.W. Coons, E.C. Prenger, J.F. Kerrigan, S.B. Seminara. Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1., Hormone Research in Paediatrics, 73, 312-319, 2010
  • Head E, V.N. Nukala, K.A. Fenoglio, B.A. Muggenburg, C.W. Cotman, P.G. Sullivan. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging., Experimental Neurology, 220 (1), 171-6, 2009
  • Fenoglio-Simeone K.A., A. Mazarati, S. Sefidvash-Hockley, D. Shin, J. Wilke, H. Milligan, R. Sankar, J.M. Rho, R. Maganti. Anticonvulsant effects of the selective melatonin receptor agonist ramelteon., Epilepsy and Behavior, 16 (1), 52-7, 2009
  • Fenoglio-Simeone K.A., J.C.Wilke, H.L. Milligan, C.N. Allen, J.M. Rho, R.K. Maganti. Ketogenic Diet Treatment Improves Diurnal Rhythmicity and Abolishes Seizure Periodicity in Epileptic Kcna1-null Mice., Epilepsia, 50 (9), 2027-34, 2009
  • Kim DY, Fenoglio (Simeone) KA, Kerrigan JF, Rho JM. Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas., Epilepsy Research, 83 (1), 89-93, 2009

Publications

  • Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice. KA Simeone, JM Rho, N Jain, TA Simeone., 64th Annual Meeting of the American Epilepsy Society, 2010
  • ‘Creighton Pharmacology Professors Probe Mysteries Surrounding Epilepsy'. Interviewed by CUSOM Newsletter to discuss our latest research of how food can have anti-seizure effects in epilepsy. http://medschool.creighton.edu/medicine/newscurrent/simeones/index.php
  • ‘Exploring Epilepsy’ Onwards and Upwards. Interviewed by International Innovation. 174: 109-111. http://www.internationalinnovation.com/exploring-epilepsy/

Presentations

  • Iyer S, Matthews SA, Smason KK, Simeoen KA, Simeone TA. Antiseizure Effects of Ketogenic Diet Are Mediated Via Regulation of Brain PPAR-Gamma, A Nutritionally Responsive Transcription Factor. Antiseizure Drug Development Symposium: Therapy Development in the Era of Team Science and Big Data: What Will the Future Bring to the Patient with Epilepsy? Salt Lake City, UT., 2015
  • Preliminary evidence of adaptive immune cell infiltration into the brain of a genetic model of chronic epilepsy. Antiseizure Drug Development Symposium: Therapy Development in the Era of Team Science and Big Data: What Will the Future Bring to the Patient with Epilepsy? Salt Lake City, UT., 2015
  • Effects of Dual orexin receptor antagonist treatment improves sleep and reduces seizures in Kv1.1KO mice. Antiseizure Drug Development Symposium: Therapy Development in the Era of Team Science and Big Data: What Will the Future Bring to the Patient with Epilepsy? Salt Lake City, UT., 2015
  • Sleepless and Hyperexcitable,’ Biomedical Science Seminar Series, University of California at Riverside, Riverside, CA., 2015
  • Department Research Rounds, CUSOM. Title: A tale of two tales: mitochondria and the ketogenic diet, 2015
  • Orexinergic activity and seizure propagation to the lateral hypothalamus. St. Albert's Day, 2015
  • ‘Mitochondria as a Novel Anti-Seizure Target,’ Biochemistry Seminar Series,CUSOM, Omaha, NE., 2015
  • Simeone TA, Matthews SA, Samson KK, Simeone KA. PPARgamma mediates ketogenic diet anti-seizure efficacy. American Epilepsy Society, Seattle, WA., 2014
  • Consequences of seizure propagation to the sleep regulating lateral hypothalamus. Society for Neuroscience, Washington D.C., 2014
  • Use of Reversed-Phase High Performance Liquid Chromatography to Measure Adenosine Amounts in Mouse Brain. ACS Midwest Regional Meeting - Columbia, MO., 2014
  • Invited speaker: ‘Epilepsy, sleep and mitochondria,’ University of Nebraska Medical Center, Current and Future Directions for Translational Epilepsy Research Symposium., 2014
  • University of Nebraska Medical Center, Department of Neurological Sciences. Current and Future Directions for Translational Epilepsy Research Seminar. Title: Epilepsy, sleep and mitochondria., 2014
  • Invited Speaker: ‘Seizure Propagation to the Lateral Hypothalamus and Sleep-Wake Triggers’ Oregon Health Science University, Portland, OR, 2014
  • ‘Mitochondria, Neurotransmission and Epilepsy’ Biomedical Science Research Series, Creighton University School of Medicine, Omaha, NE, 2014
  • 'Effects of the dual orexin receptor antagonist almorexant on sleep in the Kcna1-null mouse model of epilepsy'. HM Roundtree, CC Johnson, SA Matthews, TA Simeone, KA Simeone at MSRB, Omaha, NE, 2014
  • 'Effects of the dual orexin receptor antagonist almorexant on sleep in the Kcna1-null mouse model of epilepsy'. HM Roundtree, CC Johnson, SA Matthews, TA Simeone, KA Simeone at St. Albert’s Day, Creighton University, Omaha, NE, 2014
  • Interviewed by Malorie Maddox of WOWT News in a piece titled ‘Food For Thought’ to discuss how what you eat influences your brain, December 5, 2013. http://www.wowt.com/video?videoid=2732523, 2013
  • Simeone KA. A Novel Mitochondria-targeted Anticonvulsant Treatment. 2013 Curing the Epilepsies meeting, NINDS, Bethesda, MD., 2013
  • Simeone KA, Stephanie A. Matthews SA, Samson KK, Simeone TA. A Novel Mitochondria-targeted Anticonvulsant Treatment. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • J. F. Kerrigan, A. Parsons, K. Simeone, J. Wu, J. Beggs, S. Coons.SMALL AND LARGE NEURONS FROM HUMAN EPILEPTIC HYPOTHALAMIC HAMARTOMA: GOLGI ANALYSIS OF SURGICALLY-RESECTED TISSUE.American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Roundtree HM, Samson KK, Simeone TA, Simeone KA. Evidence of Pathology in the Lateral Hypothalamus: A Connection Between Sleep Disorder and Epilepsy in the Kv1.1 Knock-Out Mouse. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Ranade NP, Samson KK, Simeone KA, Simeone TA. Anticonvulsant Effects of Pioglitazone on High Potassium Seizure-Like Events in in vitro Hippocampal Slices. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Samson KK, Simeone KA, Rho JM, Simeone TA. Effects of Ketogenic Diet and Constituents on Pathologic Sharp Waves and High Frequency Oscillations. American Epilepsy Society, San Diego, CA, December, 2012., 2012
  • Simeone KA, Roundtree HM, Samson KK, Simeone TA. Pathologic Hypocretin Circuitry: A Novel Mechanism of Sleep Disorders Associated with Epilepsy in Kv1.1 Knock-Out Mice. Creighton University, The Faculty Club Research at Center Stage, October, 2012., 2012
  • Sleep Disorder Co-morbidities Associated with Epilepsy: The Role of Adenosine Type 1 Receptor (A1R) in the Hypothalamus, 2012
  • Pathologic Hypocretin Circuitry: A Novel Mechanism of Sleep Disorders Associated with Epilepsy in Kv1.1 Knock-Out Mice, 2011
  • Loss of Kv1.1 alpha Subunit Alters Hippocampal Sharp Wave-Ripple Complexes and Promotes the Emergence of Pathologic Fast Ripples, 2011
  • Medical Student Research Interest Group: Epilepsy and Novel Anticonvulsant Therapies, 2011
  • American Epilepsy Society, San Antonio, TX. “Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice.” Poster Presenter. KA Simeone, JM Rho, N Jain, TA Simeone., 2010
  • “Mitochondria, Metabolism and Epilepsy,” University of Nebraska at Lincoln, Department of Biochemistry & Redox Biology Center, 2010
  • “Normal Network Emergent Properties Hijacked by an Epileptic Brain.” TA Simeone, KA Simeone, KA Samson, JM Rho. Creighton University, The Faculty Club Research at Center Stage., 2010
  • “Pathologic Mitochondria and Refractory Epilepsy: Carbamazepine (CBZ) Directly Modulates Mitochondrial Function in Wild-Type and Epileptic Mice.” Poster Presenter. KA Simeone, JM Rho, N Jain, TA Simeone. Creighton University, The Faculty Club Research at Center Stage., 2010
  • Invited Speaker: “Epilepsy, Sleep Disorders and Adenosine,” Brown University, William C. Dement Sleep and Chronobiology Summer Research Apprenticeship Program, Providence RI., 2010
  • Simeone, K.A. Epilepsy and Sleep Disorders, 2010
  • A. Strobel, K.A. Simeone, S.W. Coons, J.F. Kerrigan. Cellular Density of Human Hypothalamic Hamartomas., 2009
  • "Epilepsy and Sleep Disorders" Creighton University School of Medicine, 2009
  • “Translational research: Human epileptic hypothalamic hamartoma tissue” Creighton University School of Medicine., 2009
  • Invited Speaker: ‘Mechanisms of Epileptogenesis in Human Hypothalamic Hamartoma.’ Neuroscience Symposium, Arizona State University, Phoenix, AZ, 2008
  • Invited Speaker: ‘Epileptogenicity in Human epileptic Tissue In Vitro,’Epilepsy Research Rounds, Barrow Neurological Institute, Phoenix, AZ, 2008
  • Invited Speaker: ‘A Planar Multielectrode Array Analysis of Resected Human Hypothalamic Hamartoma Tissue,’ Winter Conference on Brain Research, Vale, CO, 2007
  • Invited Speaker: ‘Epigenetics: Methylation and Acetylation,’ University of California at Irvine, Irvine, CA, 2004

Research and Scholarship

Grant Funding Received

  • Creighton University Nebraska LB 692 Strategic Investment Title: Biomarkers for Sudden Unexpected Death in Epilepsy
  • Creighton University Health Science Strategic Investment Fund Title: Seizures and autoresuscitation
  • Center for Undergraduate Research and Scholarship Faculty Research Fund at Creighton University Title: Respiratory dysfunction precedes sudden death in epilepsy
  • Citizens United for Research in Epilepsy Title: Orexin triggers autonomic destabilization in SUDEP
  • National Institutes of Health, NINDS R01 NS085389 Title: PPARgamma, Epilepsy and Therapeutics. Role: Co-I
  • National Institute of Health, NINDS R01 NS072179 Title: Adenosine, Hypocretin and Sleep disorder co-morbidities Associated Epilepsy
  • Creighton University Nebraska LB 692 New Initiatives Research Grant Program
  • Epilepsy Foundation of America Title: Mitochondrial Impairment During Epileptogenesis
  • Creighton University School of Medicine Health Future Foundation Faculty Start-up Funds
  • Creighton University Heath Future Foundation Title: The Role of Hypocretin in the Sleep Disorders of Epilepsy
  • Takeda Pharmaceuticals Title: Efficacy of Ramelteon in Animal Models of Chronic Limbic Epilepsy: A Pilot Study
  • Barrow Neurological Foundation, St Joseph's Hospital Multi-electrode recordings of human epileptic hypothalamic hamartoma tissue.
  • National Institutes of Health, NINDS University of California at Irvine, Pre-doctoral Training Fellowship
  • National Institute of Health, NINDS R21 Title: Autoresuscitation and seizures

Awards and Honors

  • Travel award for Curing the Epilepsies: Pathways Forward Conference, NIH/NINDS, 2013
  • Excellence in Research Award, Creighton University School of Medicine, 2012
  • Nominated and selected for AAMC Early Career Women Faculty Professional Development Seminar, AAMC, 2010
  • Young Investigator Faculty Member Award, Creighton University School of Medicine, 2012
  • Invited expert participant for the Sleep and Epilepsy Workshop, NIH-AES-Band Foundation, 2019
  • Invited expert participate for SUDEP and Epilepsy Workshop, NIH-AES, 2020