Janee B. Gelineau-vanWaes, DVM, PhD
Janee B. Gelineau-vanWaes, DVM, PhD

Janee B. Gelineau-vanWaes, DVM, PhD

Associate Professor
School of Medicine

Academic Appointments

Department

  • Pharmacology

Position

  • Associate Professor

Education

  • Washington State University,B.S.,1976-1979
  • Washington State University,DVM,1979-1983
  • Washington State University,Ph.D.,1989-1996

Publications and Presentations

Books

  • Gelineau-van Waes, J., K.A. Voss, V.L. Stevens, M.C. Speer, and R.T. Riley. Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects. Advances in Food and Nutrition Research. Steven Taylor (ed.) Elsevier/Academic Press., Not Applicable, 56, 145-181, 2009

Articles


  • Voss K,  Ryu D, Jackson L, Riley R, Gelineau-van Waes J. (2017)  Reduction of Fumonisin Toxicity by Extrusion and Nixtamalization (Alkaline Cooking).  J Agric Food Chem doi:  10.1021/acs.jafc.6b05761. [Epub ahead of print]  PMID: 28170235
     , 2017

  • Voss, KA, Riley, RT, Gardner, NM, and J. Gelineau-van Waes (April 2017) Chapter 47:  Fumonisins: Developmental Toxicity of Fumonisins, Potential Risk Factors for Neural Tube Defects. Pp. 925-944.  In:  Reproductive and Developmental Toxicology, 2nd Edition, Ramesh C. Gupta, editor.  Academic Press 2017, ISBN: 9780128042397
     , 925-944, 2017

  • Gardner NM, Riley RT, Showker JL, Voss KA, Sachs AJ, Maddox JR, Gelineau-van Waes JB. (2016)   Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts.  Toxicol Appl Pharmacol. pii: S0041-008X(16)30040-0. doi: 10.1016/j.taap.2016.02.018. [Epub ahead of print] PMID: 26905748
     , 2016

  • S. Bhattacharyya, M. Rainey, P. Arya, S. Dutta, M. George, M.D. Storck, R. D. McComb, D. Muirhead, G. L. Todd, K. Gould, K. Dutta, J. Gelineau-van Waes, V. Band, and H. Band (2016)  Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.  Scientific Reports. Feb. 17;6:20727. Doi: 10.1038/srep20727.  PMID: 26884322.
     , 17(6), 20727, 2016

  • Nicole M. Gardner; Ronald T. Riley; Jency L. Showker; Kenneth A. Voss; Andrew J. Sachs; Joyce R. Maddox; Janee B. Gelineau-van Waes (2016) Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.  Toxicological Sciences, 150(1):161-8. PMID: 26719367
     , 150(1), 161-8, 2016

  • Riley RT, Torres O, Matute J, Gregory SG, Ashley-Koch AE, Showker JL, Mitchell T, Voss KA, Maddox JR, Gelineau-van Waes JB. (2015)  Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala.  , Mol Nutr Food Res. 59(11):2209-24. , 2209-24., 2015
  • A Blood Spot Method for Detecting Fumonisin-Induced Changes in Putative Sphingolipid Biomarkers in LM/Bc Mice and Humans. Riley, R.T., Showker, J.L., Lee, C., Zipperer, C., Mitchell, T., Voss, K.A., Zitomer, N., Torres, O., Matute, J., Gregory, S.G., Ashley-Koch, A.E., Maddox, J., Gardner, and J. Gelineau-van Waes, Food Additives and Contaminants, 32 (6) , 934 - 949, 2015
  • Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study. Torres, O., Matute, J., Gelineau-van Waes, J., Maddox, J., Gregory, S.G., Ashley-Koch, A.E., Showker, J.L., Voss, K.A., and R.T. Riley, World Mycotoxin Journal, 8 (2), 143 - 159, 2015
  • Fumonisin B1 induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet. Voss KA, Riley RT, Gelineau-van Waes J., Molecular Nutrition & Food Research, 58(6), 1190-8, 2014
  • Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study. Torres, O., Matute, J., Gelineau-van Waes, J., Maddox, J., Gregory, S.G., Ashley-Koch, A., Showker, J.L., Voss, K.A., and Riley, R.T., World Mycotoxin Journal, in press, 2014
  • Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala. Torres O, Matute J, Gelineau-van Waes J, Maddox JR, Gregory SG, Ashley-Koch AE, Showker JL, Zitomer NC, Voss KA, Riley RT., Molecular Nutrition & Food Research, 58(5), 973-983, 2014
  • Riley, R.T., Torres, O., Showker, J.L., Zitomer, N.C., Matute, J., Voss, K.A., Gelineau-van Waes, J., Maddox, J., Gregory, S.G., Ashley-Koch, A.E. (2012) The Kinetics of Urinary Fumonisin B1 Excretion in Humans Consuming Maize-Based Diets., Journal of Molecular Nutrition and Food Research, 56, 1445-1455, 2012
  • Riley, R.T., Voss, K.A., Showker, J.L., Torres, O., Matute, J., Maddox, J.R., Rainey, M.A., Gardner, N.M., Sachs, A., Gregory, S.G., Ashley-Koch, A.E., Krupp, D., and Gelineau-Van Waes, J. (2012) Development of Biomarkers to Assess Fumonisin Exposure and Birth Defects. In: World Nutrition Forum 2012 pp. 249-256, E.M. Binder, ed., Anytime Publishing, Leicesterhire, England, Not Applicable, World Nutrition Forum 2012, 249-256, 2012
  • Gelineau-van Waes, J., Rainey, M.A., Maddox, J.R., Voss, K.A., Sachs, A.J., Gardner, N.M., Wilberding, J.D., Riley, R.T (2012) Increased Sphingoid Base-1-Phosphates and Failure of Neural Tube Closure After Exposure to Fumonisin or FTY720., Not Applicable, 94, 2012
  • The kinetics of urinary fumonisin B(1) excretion in humans consuming maize-based diets. Riley RT, Torres O, Showker JL, Zitomer NC, Matute J, Voss KA, Gelineau-van Waes J, Maddox JR, Gregory SG, Ashley-Koch AE, Journal of Molecular Nutrition and Food Research, PMID:22815244, 2012
  • DEVELOPMENT OF BIOMARKERS TO ASSESS FUMONISIN EXPOSURE AND BIRTH DEFECTS IN GUATEMALA RONALD T. RILEY 1, KENNETH A.VOSS1, JENCY L. SHOWKER1, OLGA TORRES2, JORGE MATUTE2, JANEE GELINEAU-VAN WAES3, JOYCE R. MADDOX3, MARK. A. RAINEY3,NICOLE M. GARDNER3, ANDREW SACHS3, SIMON G. GREGORY4, ALLISON E. ASHLEY-KOCH4, DEIDRE KRUPP4, World Nutrition Forum, 2012
  • Voss, K.A., R.T. Riley, and J. Gelineau-van Waes. Chapter 53: Fumonisins: Developmental Toxicity of Fumonisins: Potential Risk Factor for Neural Tube Defects, In: Reproductive and Developmental Toxicology, Ramesh Gupta (ed.), Elsevier Ltd., Oxford, UK ISBN: 978-0123820327., Not Applicable, 725-737, 2011
  • Gelineau-van Waes, J. Chapter 12: Fumonisin, Folate and Neural Tube Defects. In: Developmental Toxicology (Knudsen/Daston, eds), Comprehensive Toxicology, 2nd edition, Charlene McQueen (ed.); Elsevier Ltd., Oxford, UK (August 2010), pp. 189-208. ISBN: 978-0080468686., Not Applicable, Vol. 12, 2010
  • Voss, K.A., R.T. Riley, M.E. Snook, and J. Gelineau-van Waes. Comparing the Reproductive and Sphingolipid Metabolic Effects of Fumonisin B1 and its Alkaline Hydrolysis Product in LM/Bc Mice: Hydrolyzed Fumonisin B1 Did Not Cause Neural Tube Defects., Toxicological sciences, 112(2), 459-467, 2009

Publications

  • Gardner, N., Riley, R.T., Torres, O., Maddox, J., Sachs, A., and Gelineau-van Waes, J. Fumonisin B1 Exposure and Increased Risk of Neural Tube Defects: A Global Health Concern, St. Albert's Day, Creighton University, Omaha, NE, St. Albert's day/Creighton University Research day, 2015
  • Gardner, N., Riley, R.T., Maddox, J., Sachs, A., and Gelineau-van Waes, J. Fumonisin B1-Induced Neural Tube Defects: Is Nuclear Sphinganine-1-Phosphate at Fault? 46th Annual Midwest Student Biomedical Research Forum, Omaha, NE, Midwest Student Biomedical Research Forum, 2015
  • Gardner, N., Riley, R.T., Torres, O., Maddox, J., Sachs, A., and Gelineau-van Waes, J. Fumonisin B1 Exposure and Increased Risk of Neural Tube Defects: A Global Health Concern, Global Health Conference Midwest, Omaha, NE, Global Health Conference Midwest, 2015

Presentations

  • Tortillas and Toxins: Fumonisin Exposure as a Risk Factor for NTDs Hot Topics Session on Washington State NTD Cluster, 54th Annual Meeting of the Teratology Society, Bellevue, WA, 2014
  • Tortillas, Toxins, and Neural Tube Defects Molecular Basis of Human Disease, University of Nebraska Medical Center, 2014
  • Gene-Environment Interactions in Susceptibility to Fumonisin-Induced Neural Tube Defects 8th International Conference on Neural Tube Defects, Austin, TX, 2013
  • Invited Seminar: NWI VA Medical Center Research Seminar Series, Omaha, NE, Dec. 7, 2012 “Tortillas, Toxins, and Neural Tube Defects”, 2012
  • Invited Speaker: March of Dimes Prematurity Summit, Omaha, NE, Oct. 15, 2012 “Tortillas, Toxins, and Neural Tube Defects”, 2012
  • Teratology Society Annual Meeting, 2012
  • Faculty Club at Center Stage, 2012
  • Neural Tube Defect Symposium, International Society for Developmental Neuroscience, Mumbai, India, “Gene-Environment Interactions in Fumonisin-Induced Neural Tube Defects: Genetic Variants and Metabolic Toxin Converge on a Bicistronic Modulator of CNS Development”, 2012
  • Southeastern Regional Lipid Conference, 2011
  • 7th International Conference on Neural Tube Defects, Austin, TX, “Gene-Environment Interactions in Fumonisin-Induced Neural Tube Defects: Genetic Variants and Metabolic Toxin Converge on a Bicistronic Modulator of CNS Development”, 2011
  • “Embryonic Development and Birth Defects: Gene-Nutrient-Environment Interactions: A Multifactorial Perspective”, 2011
  • Invited Seminar: Molecular Cell Biology Seminar Series, Creighton University, Omaha, NE, May 7, 2010 “Of Maize and Men: A Tale of Tortillas, Toxins, and Teratogens”, 2011
  • Guest Lecture: Environmental Health Sciences Webinar, University of Georgia, Athens, GA, April 14, 2011 “Food Safety and Pregnancy: Mycotoxins and Risk for Birth Defects”, 2011
  • Invited Seminar: Nebraska Wesleyan University Developmental Biology Class, Lincoln, NE, April 7, 2011 “Gestational Exposure to Fumonisin and Risk for Neural Tube Defects”, 2011
  • Invited Seminar: Biomedical Sciences Departmental Seminar, Creighton University, Omaha, NE, Feb. 28, 2011 “Tortillas, Toxins and Pregnancy: Deciphering the Enigma of Fumonisin and Birth Defects”, 2011
  • Molecular Cell Biology Seminar, 2010
  • Biology Seminar, Wesleyan University, 2010
  • Molecular Basis of Human Disease graduate lecture (UNMC), 2010
  • Dept. of Environmental Health Sciences Webinar, University of Georgia, 2010
  • Society of Toxicology, Salt Lake City, UT, 2010
  • FASEB Conference: Cilia, Signaling, and Human Disease, Monterey, CA, 2010
  • Sphingolipid Gordon Research Conference, Ventura, CA, 2010
  • BRTP822 graduate lecture (UNMC), 2009
  • BRTP822 graduate lecture (UNMC), 2009
  • BRTP822 graduate lecture (UNMC), 2009
  • Neural Tube Defect Conference, Burlington, Vermont, 2009

Research and Scholarship

Grant Funding Received

  • Neural Tube Defect Risk Factors: Fumonisin, Folate and (Epi)genetic Interactions
  • mir-574-5p Balances the Neural Progenitor Sphingolipid-APP Axis of Good and Evil
  • CerS1-Gdf1: Bicistronic Balance of Neural Stem Cell Fate
  • Mycotoxins and Birth Defects in Maize-Based Cultures: A Global Health Concern (RC4)

Awards and Honors

  • Intramural Research Award, 2010