Tejbeer Kaur, PhD
Tejbeer Kaur, PhD

Tejbeer Kaur, PhD

Assistant Professor
School of Medicine, Omaha Campus

Expertise/Specializations

  • Auditory Neuroscience
  • Hearing and Hearing Loss
  • Neuron Degeneration, Repair and Survival
  • Ototoxicity
  • Inflammation
  • Innate-Immune System
  • Mononuclear Phagocytes
  • Chemokines
  • Microglia
  • Sensory Hair Cell Damage and Loss

Academic Appointments

Department

  • Biomedical Sciences

Position

  • Assistant Professor

Biography

BS: Pharmacy, University of Delhi, India, 2005
MS: Pharmacology, University of Delhi, India,  2008
PhD: Pharmacology, Southern Illinois University, Carbondale, IL, 2012
Postdoctoral Research: Auditory Neurobiology, Washington University, St. Louis, MO, 2016

 

Publications and Presentations

Articles

  • Kaur T, Clayman AC, Nash AJ, Schrader AD, Warchol ME, Ohlemiller KK. Lack of Fractalkine Receptor on Macrophages Impairs Spontaneous Recovery of Ribbon Synapses After Moderate Noise Trauma in C57BL/6 Mice.

     , Frontiers in Neuroscience, 13:620, 2019
  • Kaur T, Ohlemiller KK, Warchol ME. Genetic disruption of fractalkine signaling leads to enhanced loss of cochlear afferents following ototoxic or acoustic injury.
     , Journal of Comparative Neurology, 526 (5), 824-835, 2018
  • Ohlemiller KK, Kaur T, Warchol ME, Withnell RH. The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.
    *Selected for Journal Cover Page
     , Hearing Research, 361, 138-151, 2018
  • Kaur T, Borse V, Sheth S, Sheehan K, Ghosh S, Tupal S, Jajoo S, Mukherjea D, Rybak LP, Ramkumar V. Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea., Journal of neuroscience : the official journal of the Society for Neuroscience, 36 (14), 3962-3977, 2016
  • Kaur T, Zamani D, Tong L, Rubel EW, Ohlemiller KK, Hirose K, Warchol ME. Fractalkine signaling regulates macrophage recruitment into the cochlea and promotes the survival of spiral ganglion neurons after selective hair cell lesion., Journal of neuroscience : the official journal of the Society for Neuroscience, 35 (45), 15050-15061, 2015
  • Tong L, Strong MK, Kaur T, Juiz JM, Oesterle EC, Hume C, Warchol ME, Palmiter RD, Rubel EW.Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons., Journal of neuroscience : the official journal of the Society for Neuroscience, 35 (20), 7878-7891, 2015
  • Kaur T, Hirose K, Rubel EW, Warchol ME. Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle., Frontiers in Cellular Neuroscience, 9:150, 2015

Presentations


  • Mihai Stancu, Ezhilarasan Rajaram, Hilde Wohlfrom, Tejbeer Kaur, Mark Warchol, Edwin W Rubel and Conny Kopp-Scheinpflug. Modulations of neural action potential rates can influence electrical properties of oligodendrocytes and myelination of individual trapezoid body axons. ARO 43rd Midwinter research meeting, January 25-29, 2020, San Jose, California.
     , 2020

  • Anna C. Clayman, Kevin K. Ohlemiller, Mark E. Warchol, Tejbeer Kaur. Lack of Macrophages Impair Spontaneous Repair of Ribbon Synapses After Synaptopathic Acoustic Trauma in C57BL/6 mice.
    ARO 43rd Midwinter research meeting, January 25-29, 2020, San Jose, California.
     , 2020

  • Van A. Redila, Ling Tong, Robin M. Gibson, Tejbeer Kaur, Mark E. Warchol, Edwin W Rubel. Influence of Macrophages and Microglia on Spiral Ganglion and Cochlear Nucleus Neuron Survival Following Selective Hair Cell Death in Mature Mice.
    ARO 43rd Midwinter research meeting, January 25-29, 2020, San Jose, California.
     , 2020

  • Tejbeer Kaur, Anna Clayman, Andrew Nash, Mark E. Warchol and Kevin K. Ohlemiller. Macrophage Regulates Ribbon Synapse Repair and Neuron Survival Via Fractalkine Signaling After Noise-Induced Cochlear Synaptopathy.  Midwest Auditory Research Conference (MARC), July 11-13, 2019, Springfield, Illinois. (*oral presentation)
     , 2019

  • Tejbeer Kaur, Erik Tycksen, Mark E. Warchol, Mike Heinz. Differential Gene Expression in FACS Sorted Mature Cochlear Neurons and Macrophages After Selective Hair Cell Ablation. ARO 42nd Midwinter research meeting, February 9-13, 2019, Baltimore, Maryland.
     , 2019

Research and Scholarship

Research and Scholarship Interests

  • To understand the biological mechanisms of neuron degeneration and their endogenous repair and survival in the mammalian auditory system with a long-term goal to develop therapies to preserve or restore hearing.

Current Research Projects

  • The mammalian hearing organ, the cochlea, contains sensory epithelium, the organ of Corti that consists of hair cells (sensory receptors) responsible for converting sound into electrical signals that are conveyed to the brain via bipolar afferent spiral ganglion neurons (SGNs). The loss of hair cells or their connections with SGNs (termed “ribbon synapses”) results in sensory neural hearing loss (SNHL). Hair cell or synaptic loss is often followed by gradual degeneration and ultimately death of SGNs. Such pathology occurs after noise overexposure, treatment with certain medications, infection or ageing and is heterogenous in nature. SNHL is often permanent, leading to lifelong challenges in speech recognition and listening in noisy environments. The primary therapies for SNHL are amplification devices, such as hearing aids, and cochlear implants. But the effectiveness of these devices is extremely limited in people whose SNHL is due to deficient or absent auditory nerve innervation and cell bodies. SGNs do not regenerate spontaneously and there are currenlty no FDA approved drugs that promote neuron survival or elicit neuron regeneration or synaptogenesis. The mechanisms of SGN degeneration and loss are poorly understood. Thus, our overarching goal is to determine the biological mechanisms of SGN degeneration, repair and survival to develop better therapies for neuroprotection and regeneration to preserve or restore hearing.
         Inflammation is a hallmark of SNHL. Macrophages (innate-immune cells), the primary responders of inflammation are increased and activated as a result of damage to the cochlea. However, the precise function of inflammation and macrophages in cochlear pathology and hearing loss remains unclear. Our research work has shed light on novel and beneficial roles of macrophages in promoting the long-term survival of auditory neurons and repair of damaged synapses in the injured cochlea (Kaur et al., J Neuroscience, 2015; Kaur et al., J Comparative Neurology, 2018; Kaur et al., Frontiers in Neuroscience, 2019). This research work has also led to the identification of a neuron-immune molecular signaling, fractalkine signaling, that can regulate neuron survival and synaptic repair in damaged cochlea. Fractalkine signaling is a unique neuron-immune-ligand-receptor pair where chemokine fractalkine (CX3CL1) is constitutively expressed on SGNs and binds to its exclusive receptor CX3CR1 expressed by macrophages. Our findings have revealed a critical role for immune system in auditory pathology and suggest that macrophages and fractalkine play a neuroprotective role in the damaged cochlea. A more complete understanding of how macrophages and fractalkine regulate neuron survival and synaptic repair will provide critical information towards developing novel immunotherapies to prevent auditory nerve degeneration or promote nerve regeneration and re-establishment of their synaptic connections and restore hearing.

    Research Techniques
    Mouse genetics, RNA sequencing, confocal imaging of fixed and live tissue, super-resolution imaging, cellular and molecular biology techniques, fluorescent immunohistochemistry, cochlear explant culture, cochlear microdissections, histology, auditory function assessment, flow cytometry, cell sorting, immunophenotyping.
    Learn more about our research here:
    https://kaurlab.weebly.com/

Grant Funding Received

  • R03 DC015320 NIH/NIDCD Period: 04/2016 – 07/2019 Role: PI $450,000 (total) Role of macrophages in noise-induced cochlear synaptopathy and neuropathy.
  • Bellucci Translational Hearing Research Fund 2020 Role: PI Peroid: 07/01/2020-06/30/2021 $65,000 (Total) Role of Macrophages in Damage and Repair of Cochlear Ribbon Synapse.

Awards and Honors

  • Guest Editor, Frontiers, 2020
  • Panelist, Molecular Biology of Hearing and Deafness (MBHD), University of Iowa, Iowa, 2021
  • Panelist, Job Search and Independence, spARO Mentoring Session, 43rd Association for Research in Otolaryngology MidWinter Meeting, 2020
  • Guest Associate Editor, Frontiers in Neuroscience and Cellular Neurophysiology , 2020
  • Co-Chair, Association for Research in Otolaryngology, 2021