Researcher receives $1.8 million NIH grant
Researcher Xian-Ming Chen, MD, a professor in the Department of Medical Microbiology and Immunology in the School of Medicine, has received a $1.8 million National Institutes of Health (NIH) grant. The award will allow him to examine how long non-coding RNA molecules are involved in the host defense from cryptosporidium in the intestinal tract.
Cryptosporidiosis is one of the leading causes of waterborne disease in the United States, and the common cause of diarrhea in young children in developing countries. For those with compromised immune systems, particularly those with late stage diagnosed HIV and other immune deficiencies, infection can result in persistent, debilitating and possibly fatal diarrhea and wasting. There is currently no known fully effective treatment available.
Ming said he hopes the study will fill the gaps in the understanding of how epithelial cells orchestrate mucosal anti-cryptosporidium defense, relevant to the development of potential new therapies.